ArticleJournal of virology1997
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Characterization of a Cytokine-Independent STAT5 Activator.Biomedicines · 2026Article
- An engineered viral protein activates STAT5 to prevent T cell suppression.Science immunology · 2025Article
- The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy.International journal of molecular sciences · 2021Review
- Human β-defensin 3 induces STAT1 phosphorylation, tyrosine phosphatase activity, and cytokine synthesis in T cells.Journal of leukocyte biology · 2013Article
- Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip.Cell communication and signaling : CCS · 2012Article
- Activation of the STAT6 transcription factor in Jurkat T-cells by the herpesvirus saimiri Tip protein.The Journal of general virology · 2012Article
- A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.PloS one · 2012Article
- Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation.Journal of virology · 2011Article
- Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.Neoplasia (New York, N.Y.) · 2009Article
- Viral modulation of T-cell receptor signaling.Journal of virology · 2008Review
- STAT3 as a target for inducing apoptosis in solid and hematological tumors.Cell research · 2008Review
- Persistent activation of STAT3 by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.Journal of virology · 2007Article
- Intracellular Tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus: role of JAK/STAT signaling.Journal of virology · 2007Article
- Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.Journal of virology · 2006Article
- Expression of Stat3 in feline mammary gland tumours and its relation to histological grade.Veterinary research communications · 2006Article
- Article
- Association of herpesvirus saimiri tip with lipid raft is essential for downregulation of T-cell receptor and CD4 coreceptor.Journal of virology · 2006Article
- T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.Journal of virology · 2005Article
- Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis.Oncogene · 2004Review
- Herpesvirus ateles Tio can replace herpesvirus saimiri StpC and Tip oncoproteins in growth transformation of monkey and human T cells.Journal of virology · 2004Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Signal transducers and activators of transcription (STATs) relay signals from activated cell surface receptors directly to the nucleus. Previously, a protein required for T-cell transformation by the DNA tumor virus herpesvirus saimiri (HVS) and designated tyrosine kinase interacting protein (Tip-484) was shown to interact with and dramatically upregulate the activity of p56lck. p56lck is a nonreceptor tyrosine kinase that is essential for signaling by the T-cell receptor and also interacts with the CD4, CD8, and interleukin-2 receptors. The present data show activation of STAT1 and -3 by Tip-484. STAT1 and -3 were also found to complex with glutathione S-transferase-Tip-484 only in the presence of p56lck, and STAT3 was shown to be phosphorylated by the Tip-484-p56lck multiprotein complex in vitro. Infection of T cells with HVS or expression of recombinant Tip-484 significantly increased the DNA-binding activity of the STAT1 and STAT3 transcription factors in nuclear extracts and also increased the phosphorylation of STAT3 in vivo. This is the first report of STAT activation by a DNA tumor virus protein. Moreover, these studies demonstrate that p56lck is required for STAT activation by Tip-484.
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