ArticleJournal of virology1997
Genetic determinant of rapid-onset B-cell lymphoma by avian leukosis virus.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Retroviral RNA Processing.Viruses · 2022Review
- Selection for avian leukosis virus integration sites determines the clonal progression of B-cell lymphomas.PLoS pathogens · 2017Article
- Avian Leukosis Virus Activation of an Antisense RNA Upstream of TERT in B-Cell Lymphomas.Journal of virology · 2016Article
- Common Viral Integration Sites Identified in Avian Leukosis Virus-Induced B-Cell Lymphomas.mBio · 2015Article
- Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein.Nucleic acids research · 2011Article
- RNA processing control in avian retroviruses.Frontiers in bioscience : a journal and virtual library · 2008Review
- The negative regulator of splicing element of Rous sarcoma virus promotes polyadenylation.Journal of virology · 2006Article
- Sequences within the gag gene of mouse mammary tumor virus needed for mammary gland cell transformation.Journal of virology · 2006Article
- Silent point mutation in an avian retrovirus RNA processing element promotes c-myb-associated short-latency lymphomas.Journal of virology · 2003Article
- Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius.Oncogene · 2003Article
- Article
- Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element.Nucleic acids research · 2002Article
- The role of overlapping U1 and U11 5' splice site sequences in a negative regulator of splicing.RNA (New York, N.Y.) · 1999Article
- An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus.Molecular and cellular biology · 1998Article
- Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.Journal of virology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Infection of 10 day-old chicken embryos with the recombinant avian leukosis virus (ALV) EU-8 induces a high incidence of rapid-onset B-cell lymphoma by insertional activation of the c-myb gene. LR-9, a related ALV with differences from EU-8 in the gag and pol genes, induces rapid-onset lymphoma at only a low incidence. To localize the viral determinant(s) responsible for this biologic difference, we constructed and tested a series of reciprocal chimeras between EU-8 and LR-9 ALVs. The ability to induce rapid-onset lymphoma efficiently was localized to a 925-nucleotide (nt) region of the EU-8 gag gene. Sequence analysis of the region revealed a 42-nt deletion in EU-8 relative to LR-9, as well as some single-nucleotide changes. A mutant virus, delta LR-9, constructed by deleting these 42 nt from LR-9, also induced rapid-onset lymphoma at a high frequency, confirming the biologic significance of this deletion. This deletion removed nt 735 to 776, which lies within a cis-acting RNA element that negatively regulates splicing (NRS). The deletion was shown to cause an increase in splicing efficiency, which may lead to increased production of a truncated myb gene product from an ALV-myb readthrough RNA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.