ArticleJournal of bacteriology1997
Protection of DNA during oxidative stress by the nonspecific DNA-binding protein Dps.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
179 citing papers in PubMed, 458 citations in OpenAlex.
- The natural history of a biocrust architect, the cyanobacterium Microcoleus vaginatus.FEMS microbiology reviews · 2026Review
- Dormancy in Non-Spore-Forming Bacteria: A Review.Microorganisms · 2025Review
- Structural and Binding Properties of Dps - A Nucleoid Associated Protein.bioRxiv : the preprint server for biology · 2025Article
- Self-Assembled Ferritin Nanoparticles for Delivery of Antigens and Development of Vaccines: From Structure and Property to Applications.Molecules (Basel, Switzerland) · 2024Review
- Quantitative morphological analysis ofApplied and environmental microbiology · 2024Article
- Bridging DNA contacts allow Dps from E. coli to condense DNA.Nucleic acids research · 2024Article
- Article
- RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024Review
- Bridging DNA contacts allow Dps frombioRxiv : the preprint server for biology · 2024Article
- Growth of soil ammonia-oxidizing archaea on air-exposed solid surface.ISME communications · 2024Article
- Metabolic versatility of soil microbial communities below the rocks of the hyperarid Dalangtan Playa.Applied and environmental microbiology · 2023Article
- Mobilization of iron stored in bacterioferritin, a new target for perturbing iron homeostasis and developing antibacterial and antibiofilm molecules.Journal of inorganic biochemistry · 2023Review
- Dps Functions as a Key Player in Bacterial Iron Homeostasis.ACS omega · 2023Review
- Article
- Temperature Matters: Bacterial Response to Temperature Change.Journal of microbiology (Seoul, Korea) · 2023Review
- Article
- Immuno-profiling ofFrontiers in microbiology · 2023Article
- Transposon-Directed Insertion-Site Sequencing Reveals Glycolysis GeneAntioxidants (Basel, Switzerland) · 2022Article
- Chemistry and Bioactivity ofMolecules (Basel, Switzerland) · 2022Article
- Identifying the mediators of intracellular E. coli inactivation under UVA light: The (photo) Fenton process and singlet oxygen.Water research · 2022Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species can damage most cellular components, but DNA appears to be the most sensitive target of these agents. Here we present the first evidence of DNA protection against the toxic and mutagenic effects of oxidative damage in metabolically active cells: direct protection of DNA by Dps, an inducible nonspecific DNA-binding protein from Escherichia coli. We demonstrate that in a recA-deficient strain, expression of Dps from an inducible promoter prior to hydrogen peroxide challenge increases survival and reduces the number of chromosomal single-strand breaks. dps mutants exhibit increased levels of the G x C-->T x A mutations characteristic of oxidative damage after treatment with hydrogen peroxide. In addition, expression of Dps from the inducible plasmid reduces the frequency of spontaneous G x C-->T x A and A x T-->T x A mutations and can partially suppress the mutator phenotype of mutM (fpg) and mutY alleles. In a purified in vitro system, Dps reduces the number of DNA single-strand breaks and Fpg-sensitive sites introduced by hydrogen peroxide treatment, indicating that the protection observed in vivo is a direct effect of DNA binding by Dps. The widespread conservation of Dps homologs among prokaryotes suggests that this may be a general strategy for coping with oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.