ArticleThe Journal of clinical investigation1997
Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 138 citations in OpenAlex.
- Impact of controlled type 2 diabetes on muscle-tendon mechanics.Acta diabetologica · 2026Article
- Age-Related Changes in Post-Translational Modifications of Proteins from Whole Male and Female Skeletal Elements.Molecules (Basel, Switzerland) · 2023Article
- Spectral Features Differentiate Aging-Induced Changes in Parchment-A Combined Approach of UV/VIS, µ-ATR/FTIR and µ-Raman Spectroscopy with Multivariate Data Analysis.Molecules (Basel, Switzerland) · 2023Article
- Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains.Journal of proteome research · 2022Article
- Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases.Redox biology · 2021Review
- Protein glycation - biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine.Redox biology · 2021Article
- Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN).Lipids in health and disease · 2017Article
- Guizhi Fuling Wan as a Novel Agent for Intravesical Treatment for Bladder Cancer in a Mouse Model.Molecular medicine (Cambridge, Mass.) · 2016Article
- Protein oxidation and peroxidation.The Biochemical journal · 2016Review
- Update on Mechanisms of Renal Tubule Injury Caused by Advanced Glycation End Products.BioMed research international · 2016Article
- Cardiovascular redox and ox stress proteomics.Antioxidants & redox signaling · 2012Review
- The biological significance of methionine sulfoxide stereochemistry.Free radical biology & medicine · 2011Review
- Reactive oxygen species in cancer.Free radical research · 2010Review
- Diabetic nephropathy: a disorder of oxygen metabolism?Nature reviews. Nephrology · 2010Review
- Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies.Lancet (London, England) · 2008Review
- Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.Drug metabolism and drug interactions · 2008Review
- Advanced glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia.Journal of inherited metabolic disease · 2007Article
- Formation of methionine sulfoxide during glycoxidation and lipoxidation of ribonuclease A.Archives of biochemistry and biophysics · 2007Article
- Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes.Diabetologia · 2006Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The glycoxidation products Nepsilon-(carboxymethyl)lysine and pentosidine increase in skin collagen with age and at an accelerated rate in diabetes. Their age-adjusted concentrations in skin collagen are correlated with the severity of diabetic complications. To determine the relative roles of increased glycation and/or oxidation in the accelerated formation of glycoxidation products in diabetes, we measured levels of amino acid oxidation products, distinct from glycoxidative modifications of amino acids, as independent indicators of oxidative stress and damage to collagen in aging and diabetes. We show that ortho-tyrosine and methionine sulfoxide are formed in concert with Nepsilon-(carboxymethyl)lysine and pentosidine during glycoxidation of collagen in vitro, and that they also increase with age in human skin collagen. The age-adjusted levels of these oxidized amino acids in collagen was the same in diabetic and nondiabetic subjects, arguing that diabetes per se does not cause an increase in oxidative stress or damage to extracellular matrix proteins. These results provide evidence for an age-dependent increase in oxidative damage to collagen and support previous conclusions that the increase in glycoxidation products in skin collagen in diabetes can be explained by the increase in glycemia alone, without invoking a generalized, diabetes-dependent increase in oxidative stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.