ArticleThe Journal of clinical investigation1997
A novel pathogenesis of megacolon in Ncx/Hox11L.1 deficient mice.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Altered enteric neurodevelopment in the Ncx knockout mouse model of intestinal neuronal dysplasia.Pediatric surgery international · 2025Article
- A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system.Pediatric surgery international · 2023Article
- Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.Scientific reports · 2021Article
- Role of GDNF, GFRα1 and GFAP in aFrontiers in pediatrics · 2021Article
- Effect of Neuroligin1 and Neurexin1 on the Colonic Motility in a Mouse Model of Neuronal Intestinal Dysplasia.Gastroenterology research and practice · 2020Article
- Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment.BMC genomics · 2017Article
- Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.Developmental biology · 2016Review
- Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Knockout mouse models of Hirschsprung's disease.Pediatric surgery international · 2015Review
- Classification and diagnostic criteria of variants of Hirschsprung's disease.Pediatric surgery international · 2013Review
- Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.The EMBO journal · 2010Article
- Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction.The Journal of clinical investigation · 2009Article
- Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice.Pediatric surgery international · 2009Article
- Article
- Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease.Neurogastroenterology and motility · 2009Review
- Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.Developmental biology · 2008Article
- [Intestinal neuronal dysplasia type B: how do we understand it today?].Der Pathologe · 2007Article
- Enteric nervous system and developmental abnormalities in childhood.Pediatric surgery international · 2006Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ncx/Hox11L.1 gene, a member of the Hox11 homeobox gene family, is mainly expressed in neural crest-derived tissues. To elucidate the role of Ncx/Hox11L.1, the gene has been inactivated in embryonic stem cells by homologous recombination. The homozygous mutant mice were viable. These mice developed megacolon with enteric ganglia by age 3-5 wk. Histochemical analysis of the ganglia revealed that the enteric neurons hyperinnervated in the narrow segment of megacolon. Some of these neuronal cells degenerated and neuronal cell death occurred in later stages. We propose that Ncx/Hox11L.1 is required for maintenance of proper functions of the enteric nervous system. These mutant mice can be used to elucidate a novel pathogenesis for human neuronal intestinal dysplasia.
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