ArticleGenetics1997
Allelic specificity at the het-c heterokaryon incompatibility locus of Neurospora crassa is determined by a highly variable domain.
Article in Genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- TheJournal of fungi (Basel, Switzerland) · 2026Article
- The Narrow Footprint of Ancient Balancing Selection Revealed by Heterokaryon Incompatibility Genes in Aspergillus fumigatus.Molecular biology and evolution · 2024Article
- Exploring the genomic diversity of black yeasts and relatives (Studies in mycology · 2017Article
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- MITEs in the promoters of effector genes allow prediction of novel virulence genes in Fusarium oxysporum.BMC genomics · 2013Article
- Article
- Transcriptional profiling and functional analysis of heterokaryon incompatibility in Neurospora crassa reveals that reactive oxygen species, but not metacaspases, are associated with programmed cell death.Microbiology (Reading, England) · 2009Article
- Comparison between polyethylene glycol- and polyethylenimine-mediated transformation of Aspergillus nidulans.Current genetics · 2008Article
- The fungus-specific HET domain mediates programmed cell death in Podospora anserina.Eukaryotic cell · 2007Article
- VIB-1 is required for expression of genes necessary for programmed cell death in Neurospora crassa.Eukaryotic cell · 2006Article
- The homologue of het-c of Neurospora crassa lacks vegetative compatibility function in Fusarium proliferatum.Applied and environmental microbiology · 2006Article
- Article
- Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Eukaryotic cell · 2004Article
- Fatal attraction: nonself recognition and heterokaryon incompatibility in filamentous fungi.Eukaryotic cell · 2003Review
- Nonself recognition is mediated by HET-C heterocomplex formation during vegetative incompatibility.The EMBO journal · 2002Article
- Identification of vib-1, a locus involved in vegetative incompatibility mediated by het-c in Neurospora crassa.Genetics · 2002Article
- Multilocus self-recognition systems in fungi as a cause of trans-species polymorphism.Genetics · 2002Article
- The ham-2 locus, encoding a putative transmembrane protein, is required for hyphal fusion in Neurospora crassa.Genetics · 2002Article
- Identification of specificity determinants and generation of alleles with novel specificity at the het-c heterokaryon incompatibility locus of Neurospora crassa.Molecular and cellular biology · 2001Article
- Molecular genetics of heterokaryon incompatibility in filamentous ascomycetes.Microbiology and molecular biology reviews : MMBR · 2000Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In filamentous fungi, the ability to form a productive heterokaryon with a genetically dissimilar individual is controlled by specific loci termed het loci. Only strains homozygous for all het loci can establish a heterokaryon. In Neurospora crassa, 11 loci, including the mating-type locus, regulate the capacity to form heterokaryons. An allele of the het-c locus (het-cOR) of N. crassa has been previously characterized and encodes a nonessential 966 amino acid glycine-rich protein. Herein, we describe the genetic and molecular characterization of two hei-c alleles, het-cPA and het-cOR, that have a different specificity from that of het-cOR, showing that vegetative incompatibility is mediated by multiple alleles at het-c. By constructing chimeric alleles, we show that het-c specificity is determined by a highly variable domain of 34-48 amino acids in length. In this regard, het-c is similar to loci that regulate recognition in other species, such as the (S) self-incompatibility locus in plants, the sexual compatibility locus in basidiomycetes and the major histocompatibility complex (MHC) genes in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.