ArticleAntimicrobial agents and chemotherapy1997
Enhancement of nitric oxide synthesis by macrophages represents an additional mechanism of action for amphotericin B.
Article in Antimicrobial agents and chemotherapy, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Antifungal efficacy of a novel nitric oxide releasing solution in the presence of keratin.Frontiers in cellular and infection microbiology · 2026Article
- Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B-induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- The Triple Crown: NO, CO, and HPharmacology & therapeutics · 2023Review
- Repurposing Amphotericin B and Its Liposomal Formulation for the Treatment of Human Mpox.International journal of molecular sciences · 2023Article
- It only takes one to do many jobs: Amphotericin B as antifungal and immunomodulatory drug.Frontiers in microbiology · 2012Article
- Amphotericin B membrane action: role for two types of ion channels in eliciting cell survival and lethal effects.The Journal of membrane biology · 2010Review
- In search of the holy grail of antifungal therapy.Transactions of the American Clinical and Climatological Association · 2008Review
- Optimizing efficacy of Amphotericin B through nanomodification.International journal of nanomedicine · 2007Review
- Immune response and immunotherapy to Cryptococcus infections.Immunologic research · 2006Review
- Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection.Antimicrobial agents and chemotherapy · 2005Article
- Mechanisms of resistance to oxidative and nitrosative stress: implications for fungal survival in mammalian hosts.Eukaryotic cell · 2004Review
- Immunoenhancement combined with amphotericin B as treatment for experimental visceral leishmaniasis.Antimicrobial agents and chemotherapy · 2003Article
- Reactive oxygen intermediates, nitrite and IFN-gamma in Indian visceral leishmaniasis.Clinical and experimental immunology · 2001Article
- Reduction of no synthase expression and tumor necrosis factor alpha production in macrophages by amphotericin B lipid carriers.Antimicrobial agents and chemotherapy · 2001Article
- In vitro reversion of amphotericin B resistance in Leishmania donovani by poloxamer 188.Antimicrobial agents and chemotherapy · 2000Article
- Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis.Infection and immunity · 2000Article
- Article
- Amphotericin B and fluconazole affect cellular charge, macrophage phagocytosis, and cellular morphology of Cryptococcus neoformans at subinhibitory concentrations.Antimicrobial agents and chemotherapy · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Amphotericin B (AmB) enhanced nitrite synthesis by murine macrophage-like J774.16 cells in a dose-dependent fashion. This effect was retained in the presence of Cryptococcus neoformans capsular polysaccharide, a known virulence factor. AmB and anticapsular antibody increased nitrite synergistically. In all cases, AmB required gamma interferon; C. neoformans cells were unable to elicit nitrite, with or without AmB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.