ArticleAntimicrobial agents and chemotherapy1997
An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.
Article in Antimicrobial agents and chemotherapy, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of Antibiotic Resistance Proteins via MiCId's Augmented Workflow. A Mass Spectrometry-Based Proteomics Approach.Journal of the American Society for Mass Spectrometry · 2022Article
- Review
- Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.Nature reviews. Microbiology · 2009Review
- Inter-kingdom signalling: communication between bacteria and their hosts.Nature reviews. Microbiology · 2008Review
- Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii.Journal of bacteriology · 2006Article
- Role of CysE in production of an extracellular signaling molecule in Providencia stuartii and Escherichia coli: loss of CysE enhances biofilm formation in Escherichia coli.Journal of bacteriology · 2004Article
- Interspecies communication in bacteria.The Journal of clinical investigation · 2003Review
- A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factor.Journal of bacteriology · 1999Article
- Identification of pel, a Streptococcus pyogenes locus that affects both surface and secreted proteins.Journal of bacteriology · 1999Article
- Escherichia coli genes regulated by cell-to-cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Aminoglycosides: activity and resistance.Antimicrobial agents and chemotherapy · 1999Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromosomal aac(2')-Ia gene in Providencia stuartii encodes a housekeeping 2'-N-acetyltransferase [AAC(2')-Ia] involved in the acetylation of peptidoglycan. In addition, the AAC(2')-Ia enzyme also acetylates and confers resistance to the clinically important aminoglycoside antibiotics gentamicin, tobramycin, and netilmicin. Expression of the aac(2')-Ia gene was found to be strongly influenced by cell density, with a sharp decrease in aac(2')-Ia mRNA accumulation as cells approached stationary phase. This decrease was mediated by the accumulation of an extracellular factor, designated AR (for acetyltransferase repressing)-factor. AR-factor was produced in both minimal and rich media and acted in a manner that was strongly dose dependent. The activity of AR-factor was also pH dependent, with optimal activity at pH 8.0 and above. Biochemical characterization of conditioned media from P. stuartii has shown that AR-factor is between 500 and 1,000 Da in molecular size and is heat stable. In addition, AR-factor was inactivated by a variety of proteases, suggesting that it may be a small peptide.
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