ReviewSports medicine (Auckland, N.Z.)1997
Beta-endorphin response to exercise. An update.
Review in Sports medicine (Auckland, N.Z.), 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 278 citations in OpenAlex.
- Comparative effectiveness of exercise interventions for primary dysmenorrhea: a systematic review and network meta-analysis.BMC women's health · 2024Pooled it
- Effect of exercise type on smoking cessation: a meta-analysis of randomized controlled trials.BMC research notes · 2017Pooled it
- A meta-analytic review of the hypoalgesic effects of exercise.The journal of pain · 2012Pooled it
- Acute Clinical Effects of Dual-Task Resistance Exercise on Muscle Endurance and Pressure Sensitivity in Patients With Carpal Tunnel Syndrome After Surgery.Musculoskeletal care · 2026Trial
- Trial
- Metabolic Syndrome and Psychological Effects of Exercise in Hemodialysis Patients.International journal of environmental research and public health · 2021Trial
- Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals.Molecular psychiatry · 2020Trial
- Magnitude of exercise-induced β-endorphin response is associated with subsequent development of altered hypoglycemia counterregulation.The Journal of clinical endocrinology and metabolism · 2012Trial
- Hormonal responses to opioid receptor blockade: during rest and exercise in cold and hot environments.European journal of applied physiology · 2006Trial
- Effects of recreational physical activity and back exercises on low back pain and psychological distress: findings from the UCLA Low Back Pain Study.American journal of public health · 2005Trial
- The Neurochemical Orchestra of the Runner's High: A Narrative Review of Neuromodulatory Mechanisms with a Focus on Endocannabinoids.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Exploring the role of beta-endorphin in activity-based anorexia in mice.Physiological reports · 2025Article
- Article
- Associations between ultra-processed food consumption and duration of exercise with psychological symptoms in Chinese adolescents: a nationwide cross-sectional survey.Frontiers in nutrition · 2025Article
- Evolution of the Quality of Life of Long-Term Fibromyalgia Users of Millimeter Wave-Based Neuromodulation: A Real-World Retrospective Study.Journal of pain research · 2025Article
- Effects of Apnea-Induced Hypoxia on Hypoalgesia in Healthy Subjects.Sports (Basel, Switzerland) · 2024Article
- Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing.International journal of molecular sciences · 2024Review
- Combined Exercise and Diet Induce Airway Hyperreactivity While Reducing Liver Steatosis in Mice with Diet-Induced Obesity.Nutrients · 2024Article
- The Perceived Benefits and Self-Efficacy of an Exercise Intervention on Tobacco Withdrawal Symptoms: A Qualitative Study Based on the Health Belief Model.The Malaysian journal of medical sciences : MJMS · 2024Article
- The Nexus of Training Duration, Body Image, Nutritional Practices, and Mental Health: Insights from a Strength Training Cohort.Behavioral sciences (Basel, Switzerland) · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-Endorphin, a 31-amino-acid peptide, is primarily synthesised in the anterior pituitary gland and cleaved from pro-opiomelanocortin, its larger precursor molecule. beta-Endorphin can be released into the circulation from the pituitary gland or can project into areas of the brain through nerve fibres. Exercise of sufficient intensity and duration has been demonstrated to increase circulating beta-endorphin levels. Previous reviews have presented the background of opioids and exercise and discussed the changes in beta-endorphin levels in response to aerobic and anaerobic exercise. The present review is to update the response of beta-endorphin to exercise. This review suggests that exercise-induced beta-endorphin alterations are related to type of exercise and special populations tested, and may differ in individuals with health problems. Additionally, some of the possible mechanisms which may induce beta-endorphin changes in the circulation include analgesia, lactate or base excess, and metabolic factors. Based on the type of exercise, different mechanisms may be involved in the regulation of beta-endorphin release during exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.