ArticleProceedings of the National Academy of Sciences of the United States of America1997
Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 96 citations in OpenAlex.
- The olfactory epithelium as a port of entry in neonatal neurolisteriosis.Nature communications · 2018Article
- Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells.Blood advances · 2018Article
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- OxLDL or TLR2-induced cytokine response is enhanced by oxLDL-independent novel domain on mouse CD36.Immunology letters · 2011Article
- Potentiation of epithelial innate host responses by intercellular communication.PLoS pathogens · 2010Article
- The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Induction of Specific CD8 T Cells against Intracellular Bacteria by CD8 T-Cell-Oriented Immunization Approaches.Journal of biomedicine & biotechnology · 2010Article
- Interleukin-1 receptor type 1 is essential for control of cerebral but not systemic listeriosis.The American journal of pathology · 2007Article
- Escherichia coli prevents phagocytosis-induced death of macrophages via classical NF-kappaB signaling, a link to T-cell activation.Infection and immunity · 2006Article
- Directed antigen delivery as a vaccine strategy for an intracellular bacterial pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Listeriolysin O-induced membrane permeation mediates persistent interleukin-6 production in Caco-2 cells during Listeria monocytogenes infection in vitro.Infection and immunity · 2005Article
- NF-kappaB activation during Rickettsia rickettsii infection of endothelial cells involves the activation of catalytic IkappaB kinases IKKalpha and IKKbeta and phosphorylation-proteolysis of the inhibitor protein IkappaBalpha.Infection and immunity · 2005Article
- Induction of protective cellular immunity against Mycobacterium tuberculosis by recombinant attenuated self-destructing Listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPB/MPT51.Infection and immunity · 2004Article
- Pseudomonas aeruginosa slime glycolipoprotein is a potent stimulant of tumor necrosis factor alpha gene expression and activation of transcription activators nuclear factor kappa B and activator protein 1 in human monocytes.Infection and immunity · 2003Article
- Listeria pathogenesis and molecular virulence determinants.Clinical microbiology reviews · 2001Review
- alpha(v)beta(3) integrin and bacterial lipopolysaccharide are involved in Coxiella burnetii-stimulated production of tumor necrosis factor by human monocytes.Infection and immunity · 2000Article
- Listeria monocytogenes-infected human dendritic cells: uptake and host cell response.Infection and immunity · 2000Article
- Involvement of protein kinase C in Rickettsia rickettsii-induced transcriptional activation of the host endothelial cell.Infection and immunity · 1999Article
- Review
- Mutagenesis of active-site histidines of Listeria monocytogenes phosphatidylinositol-specific phospholipase C: effects on enzyme activity and biological function.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As previously reported, Listeria monocytogenes infection of P388D1 macrophages results in a rapid induction of NF-kappaB DNA-binding activity. Here we show that this induction of NF-kappaB activity occurs in a biphasic mode: first, a transient, IkappaBalpha degradation-dependent phase of activity, also induced by the nonvirulent species Listeria innocua, which is mediated by binding of the bacteria to the macrophage, or by adding Listeria-derived lipoteichoic acid to the macrophage; the second persistent phase of activation is only markedly induced when the bacteria enter the cytoplasm of the host cell and express the virulence genes plcA and plcB, encoding two phospholipases. We suggest that products of the enzymatic activity of phospholipases directly interfere with host cell signal transduction pathways, thus leading to persistent NF-kappaB activation via persistent IkappaBbeta degradation.
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