ArticleProceedings of the National Academy of Sciences of the United States of America1997
Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 143 citations in OpenAlex.
- B-cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells.Immunological reviews · 2022Review
- Antibody repertoire analysis in polygenic autoimmune diseases.Immunology · 2018Review
- Epigenetic Control of B Cell Development and B-Cell-Related Immune Disorders.Clinical reviews in allergy & immunology · 2016Review
- Receptor editing and genetic variability in human autoreactive B cells.The Journal of experimental medicine · 2016Article
- B cell biology: an overview.Current allergy and asthma reports · 2014Review
- Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?Current opinion in immunology · 2014Review
- Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire.Immunologic research · 2013Review
- Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity.The Journal of experimental medicine · 2013Article
- Article
- Role of recombination activating genes in the generation of antigen receptor diversity and beyond.Immunology · 2012Review
- Immunological aspects in chronic lymphocytic leukemia (CLL) development.Annals of hematology · 2012Review
- Experimental models of B cell tolerance in transplantation.Seminars in immunology · 2012Review
- Central B-cell tolerance: where selection begins.Cold Spring Harbor perspectives in biology · 2012Article
- Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.Nature immunology · 2008Article
- Understanding B-cell tolerance through the use of immunoglobulin transgenic models.Immunologic research · 2008Review
- Reduced receptor editing in lupus-prone MRL/lpr mice.The Journal of experimental medicine · 2007Article
- Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.Molecular and cellular biology · 2007Article
- Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In pre-B lymphocytes, productive rearrangement of Ig light chain genes allows assembly of the B cell receptor (BCR), which selectively promotes further developmental maturation through poorly defined transmembrane signaling events. Using a novel in vitro system to study immune tolerance during development, we find that BCR reactivity to auto-antigen blocks this positive selection, preventing down-regulation of light chain gene recombination and promoting secondary light chain gene rearrangements that often alter BCR specificity, a process called receptor editing. Under these experimental conditions, self-antigen induces secondary light chain gene rearrangements in at least two-thirds of autoreactive immature B cells, but fails to accelerate cell death at this stage. These data suggest that in these cells the mechanism of immune tolerance is receptor selection rather than clonal selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.