Evidence map›Paper›PMID 9256468›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1997

Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18.

Y Hagiwara, M Hirai, K Nishiyama, I Kanazawa, T Ueda, Y Sakaki, T Ito

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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  7. Review
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  12. Review
  13. What does genetics tell us about imprinting and the placenta connection?Cellular and molecular life sciences : CMLS · 2015
    Review
  14. Article
  15. Article
  16. Article
  17. A survey of tissue-specific genomic imprinting in mammals.Molecular genetics and genomics : MGG · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Y HagiwaraHuman Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108, Japan.
M Hirai
K Nishiyama
I Kanazawa
T Ueda
Y Sakaki
T Ito

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A systematic screen termed the allelic message display (AMD) was developed for the hunting of imprinted genes. In AMD, differential display PCR is adopted to image allelic expression status of multiple polymorphic transcripts in two parental mouse strains, reciprocal F1 hybrids and pooled backcross progenies. From the displayed patterns, paternally and maternally expressed transcripts can be unequivocally identified. The effectiveness of AMD screening was clearly demonstrated by the identification of a paternally expressed gene Impact on mouse chromosome 18, the predicted product of which belongs to the YCR59c/yigZ hypothetical protein family composed of yeast and bacterial proteins with currently unknown function. In contrast with previous screening methods necessitating positional cloning efforts or generation of parthenogenetic embryos, this approach requires nothing particular but appropriately crossed mice and can be readily applied to any tissues at various developmental stages. Hence, AMD would considerably accelerate the identification of imprinted genes playing pivotal roles in mammalian development and the pathogenesis of various diseases.

Indexed as

AllelesGenomic ImprintingAmino Acid SequenceAnimalsChromosome MappingChromosomesIntracellular Signaling Peptides and ProteinsMiceMolecular Sequence DataOrgan SpecificityProteinsSequence AlignmentSequence Homology, Amino AcidImpact protein, mouseIntracellular Signaling Peptides and ProteinsProteins

Identifiers

PMID9256468
PMCPMC23141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.