ArticleProceedings of the National Academy of Sciences of the United States of America1997
Typing of urinary JC virus DNA offers a novel means of tracing human migrations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Increased frequency of JC virus type 2 and of dual infection with JC virus type 1 and 2 in Italian progressive multifocal leukoencephalopathy patients.Journal of neurovirology · 2001Trial
- Review
- Insights into the genetic characteristics, clustering patterns, and phylogeographic dynamics of the JC polyomavirus, 1993 to 2023.Virus research · 2024Article
- John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis.Diseases (Basel, Switzerland) · 2024Review
- The complexity landscape of viral genomes.GigaScience · 2022Article
- Human Polyomaviruses (HPyV) in Wastewater and Environmental Samples from the Lisbon Metropolitan Area: Detection and Genetic Characterization of Viral Structural Protein-Coding Sequences.Pathogens (Basel, Switzerland) · 2021Article
- Viral Genomic Characterization and Replication Pattern of Human Polyomaviruses in Kidney Transplant Recipients.Viruses · 2020Observational
- Molecular epidemiology of JC polyomavirus in HIV-infected patients and healthy individuals from Iran.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Article
- From Evolutionary Advantage to Disease Agents: Forensic Reevaluation of Host-Microbe Interactions and Pathogenicity.Microbiology spectrum · 2017Review
- Assessing Host-Virus Codivergence for Close Relatives of Merkel Cell Polyomavirus Infecting African Great Apes.Journal of virology · 2016Article
- Tracing Jomon and Yayoi ancestries in Japan using ALDH2 and JC virus genotype distributions.Investigative genetics · 2015Article
- Phylogenetic analysis of beak and feather disease virus across a host ring-species complex.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular epidemiology of merkel cell polyomavirus: evidence for geographically related variant genotypes.Journal of clinical microbiology · 2014Article
- Mycobacterium leprae: genes, pseudogenes and genetic diversity.Future microbiology · 2011Review
- The role of the medical librarian in the basic biological sciences: a case study in virology and evolution.Journal of the Medical Library Association : JMLA · 2008Article
- JC virus evolution and its association with human populations.Journal of virology · 2006Article
- Genotypes of JC virus, DNA of cytomegalovirus, and proviral DNA of human immunodeficiency virus in eyes of acquired immunodeficiency syndrome patients.Journal of neurovirology · 2005Article
- Chinese strains (Type 7) of JC virus are afro-asiatic in origin but are phylogenetically distinct from the Mongolian and Indian strains (Type 2D) and the Korean and Japanese strains (Type 2A).Journal of molecular evolution · 2004Article
- Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although polyomavirus JC (JCV) is the proven pathogen of progressive multifocal leukoencephalopathy, the fatal demyelinating disease, this virus is ubiquitous as a usually harmless symbiote among human beings. JCV propagates in the adult kidney and excretes its progeny in urine, from which JCV DNA can readily be recovered. The main mode of transmission of JCV is from parents to children through long cohabitation. In this study, we collected a substantial number of urine samples from native inhabitants of 34 countries in Europe, Africa, and Asia. A 610-bp segment of JCV DNA was amplified from each urine sample, and its DNA sequence was determined. A worldwide phylogenetic tree subsequently constructed revealed the presence of nine subtypes including minor ones. Five subtypes (EU, Af2, B1, SC, and CY) occupied rather large territories that overlapped with each other at their boundaries. The entire Europe, northern Africa, and western Asia were the domain of EU, whereas the domain of Af2 included nearly all of Africa and southwestern Asia all the way to the northeastern edge of India. Partially overlapping domains in Asia were occupied by subtypes B1, SC, and CY. Of particular interest was the recovery of JCV subtypes in a pocket or pockets that were separated by great geographic distances from the main domains of those subtypes. Certain of these pockets can readily be explained by recent migrations of human populations carrying these subtypes. Overall, it appears that JCV genotyping promises to reveal previously unknown human migration routes: ancient as well as recent.
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