SynthesisEnvironmental health perspectives1997
Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis.
Synthesis in Environmental health perspectives, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Pooled it
- Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.Current genomics · 2018Article
- Association of the TP53 codon 72 polymorphism and breast cancer risk: a meta-analysis.SpringerPlus · 2014Article
- p53 codon 72 polymorphism and breast cancer risk: A meta-analysis.Experimental and therapeutic medicine · 2013Article
- Association between p53 codon 72 genetic polymorphisms and tobacco use and lung cancer risk in a Chinese population.Molecular biology reports · 2013Article
- Article
- Polymorphisms of TP53 codon 72 with breast carcinoma risk: evidence from 12226 cases and 10782 controls.Journal of experimental & clinical cancer research : CR · 2009Article
- Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population.American journal of medical genetics. Part A · 2008Article
- MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians.BMC cancer · 2008Article
- Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.BMC cancer · 2008Article
- The codon 72 polymorphism-specific effects of human p53 are absent in mouse cells: implications on generation of mouse models.Oncogene · 2007Article
- Cigarette smoke and adverse health effects: An overview of research trends and future needs.The International journal of angiology : official publication of the International College of Angiology, Inc · 2007Article
- Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients.Journal of cancer research and clinical oncology · 2006Article
- Article
- Polymorphisms in the p53 pathway.Oncogene · 2006Review
- The search for low-penetrance cancer susceptibility alleles.Oncogene · 2004Review
- The effect of a single BRCA2 mutation on cancer in Iceland.Journal of medical genetics · 2002Article
- The p53 status in juvenile chronic arthritis and rheumatoid arthritis.Clinical and experimental immunology · 2000Article
- DNA sequence variants of p53: cancer and aging.American journal of human genetics · 1999Article
- Hypermutability in carcinogenesis.Genetics · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Certain polymorphic variants of H-ras-1 and p53 have been investigated for an association between inheritance and cancer risk. The results of a metaanalysis, which reviews studies of H-ras-1 rare alleles and p53 codon 72 allelic variants in breast and lung cancer, are presented. The data constituted evidence for elevated risk of both breast and lung cancer with inheritance of rare H-ras-1 alleles. Calculated population attributable risks are 0.092 and 0.037 for breast and lung cancer, respectively. The frequency of the rare H-ras-1 alleles was observed to be greater in African Americans than in Caucasians, and a specific allele (A3.5) that is common in African Americans was found only at low frequency in Caucasians. For p53 a consensus has yet to be reached. Lung cancer studies conducted in Caucasian and African-American populations have found no evidence of risk associated with the proline variant of codon 72. Two similar studies conducted in Japanese populations suggested an association between p53 genotype distribution and lung cancer risk. However, one implicates the proline allele but the other implicates the arginine allele. The frequency of the proline variant is significantly dependent on race. Frequencies have been reported for control populations of Japanese (0.347 and 0.401), Caucasian (0.295, 0.284, and 0.214), African American (0.628 and 0.527), and Mexican American (0.263).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.