ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Granule cell activation of complex-spiking neurons in dorsal cochlear nucleus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 92 citations in OpenAlex.
- Eric Daniel Young.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Outer Hair Cell Glutamate Signaling through Type II Spiral Ganglion Afferents Activates Neurons in the Cochlear Nucleus in Response to Nondamaging Sounds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inhibitory interneurons in a brainstem circuit adjust their inhibitory motifs to process multimodal input.The Journal of physiology · 2021Article
- Evidence of activity-dependent plasticity in the dorsal cochlear nucleus, in vivo, induced by brief sound exposure.Hearing research · 2016Article
- Spontaneous Activity Defines Effective Convergence Ratios in an Inhibitory Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Responses to Social Vocalizations in the Dorsal Cochlear Nucleus of Mice.Frontiers in systems neuroscience · 2015Article
- Transcutaneous induction of stimulus-timing-dependent plasticity in dorsal cochlear nucleus.Frontiers in systems neuroscience · 2015Article
- Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus.The Journal of comparative neurology · 2014Article
- Chemical synaptic transmission onto superficial stellate cells of the mouse dorsal cochlear nucleus.Journal of neurophysiology · 2014Article
- Suppression of noise-induced hyperactivity in the dorsal cochlear nucleus following application of the cholinergic agonist, carbachol.Brain research · 2013Article
- Multi-sensory integration in brainstem and auditory cortex.Brain research · 2012Article
- Multisensory dysfunction accompanies crossmodal plasticity following adult hearing impairment.Neuroscience · 2012Article
- Single-neuron recordings from unanesthetized mouse dorsal cochlear nucleus.Journal of neurophysiology · 2012Article
- Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor α1 subunits in bushy and fusiform cells of the cochlear nucleus.Neuroscience · 2011Article
- Sustained firing of cartwheel cells in the dorsal cochlear nucleus evokes endocannabinoid release and retrograde suppression of parallel fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Spontaneous spiking and synaptic depression underlie noradrenergic control of feed-forward inhibition.Neuron · 2011Article
- Noradrenaline enhances signal-to-noise ratio of inhibitory inputs in the dorsal cochlear nucleus.Neuron · 2011Article
- Stimulus-dependent changes in optical responses of the dorsal cochlear nucleus using voltage-sensitive dye.Journal of neurophysiology · 2011Article
- Cuneate and spinal trigeminal nucleus projections to the cochlear nucleus are differentially associated with vesicular glutamate transporter-2.Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dorsal cochlear nucleus (DCN) principal cells receive, in addition to their well known auditory inputs, various nonauditory inputs via a cerebellar-like granule cell circuit located in the superficial layers of the DCN. Activation of this circuit (granule cell axons make excitatory synapses on the principal cells but also contact inhibitory interneurons that project to the principal cells) produces strong inhibition of the principal cells. Here we investigate the role of cartwheel cells, homologs of cerebellar Purkinje cells, in producing this inhibition. The responses of type IV units (one type of principal cells) and of cartwheel cells were recorded to ortho- and antidromic activation of the granule cells (i. e., by stimulation of their inputs from the somatosensory cuneate and spinal trigeminal nuclei and by direct stimulation of their parallel fiber axons). Cartwheel cells were identified on the basis of recording depth and complex action potential shape. A four-pulse facilitation paradigm (four pulses at 50 msec intervals) was used; this stimulus allows separation of the apparently simple inhibitory somatosensory response of type IV units into a three-component (inhibition-excitation-inhibition) response. As expected, cartwheel cells are excited by granule cell activation; the latencies and four-pulse amplitudes of these responses correspond to the properties of the second, long-latency inhibitory component of type IV responses. The source of the first, short-latency inhibitory response is still unknown. Nevertheless, these results show that cartwheel cells convey inhibitory polysensory information to DCN principal cells.
Indexed as
Identifiers
9254690PMC6573148W1486460857What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.