ArticleBiophysical journal1997
High-gain, low-noise amplification in olfactory transduction.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 85 citations in OpenAlex.
- Quantification of signal amplification for receptors: theFrontiers in pharmacology · 2025Article
- Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).Handbook of experimental pharmacology · 2024Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons.Scientific reports · 2018Article
- The long tale of the calcium activated ClChannels (Austin, Tex.) · 2017Review
- Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Smelling better with chloride.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons.The Journal of general physiology · 2016Article
- Cellular functions of TMEM16/anoctamin.Pflugers Archiv : European journal of physiology · 2016Review
- From molecule to mind: an integrative perspective on odor intensity.Trends in neurosciences · 2014Review
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Depolarization-induced depression of inhibitory transmission in cerebellar Purkinje cells.Physiological reports · 2013Article
- The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons.Nature neuroscience · 2012Article
- The Na(+)/Ca(2+) exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response.Nature neuroscience · 2011Article
- Mechanisms of chloride uptake in frog olfactory receptor neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Unitary response of mouse olfactory receptor neurons.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Origin of basal activity in mammalian olfactory receptor neurons.The Journal of general physiology · 2010Article
- Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells.The Journal of physiology · 2010Article
- Article
- Calcium-activated chloride current amplifies the response to urine in mouse vomeronasal sensory neurons.The Journal of general physiology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
It is desirable that sensory systems use high-gain, low-noise amplification to convert weak stimuli into detectable signals. Here it is shown that a pair of receptor currents underlying vertebrate olfactory transduction constitutes such a scheme. The primary receptor current is an influx of Na+ and Ca2+ through cAMP-gated channels in the olfactory cilia. External divalent cations improve the signal-to-noise properties of this current, reducing the mean current and the current variance. As Ca2+ enters the cilium, it gates Cl- channels, activating a secondary depolarizing receptor current. This current amplifies the primary current, but introduces little additional noise. The system of two currents plus divalent cations in the mucus produces a large receptor current with very low noise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.