ArticleBiophysical journal1997
Membrane packing geometry of diphytanoylphosphatidylcholine is highly sensitive to hydration: phospholipid polymorphism induced by molecular rearrangement in the headgroup region.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 56 citations in OpenAlex.
- The effect of PEGylation on surface tethering of liposomes via DNA nanotechnology.Journal of lipid research · 2026Article
- µ-Raman Spectroscopic Temperature Dependence Study of Biomimetic Lipid 1,2-Diphytanoyl-sn-glycero-3-phosphocholine.Biomimetics (Basel, Switzerland) · 2025Article
- Length matters: Functional flip of the short TatA transmembrane helix.Biophysical journal · 2023Article
- Studying KcsA Channel Clustering Using Single Channel Voltage-Clamp Fluorescence Imaging.Frontiers in physiology · 2022Article
- Structural Characterization of an Archaeal Lipid Bilayer as a Function of Hydration and Temperature.International journal of molecular sciences · 2020Article
- Differential interactions of bacterial lipopolysaccharides with lipid membranes: implications for TRPA1-mediated chemosensation.Scientific reports · 2018Article
- Transport-Relevant Protein Conformational Dynamics and Water Dynamics on Multiple Time Scales in an Archetypal Proton Channel: Insights from Solid-State NMR.Journal of the American Chemical Society · 2018Article
- Lipid-Detergent Phase Transitions During Detergent-Mediated Liposome Solubilization.The Journal of membrane biology · 2016Article
- Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology.The Journal of general physiology · 2016Article
- Ether- versus ester-linked phospholipid bilayers containing either linear or branched apolar chains.Biophysical journal · 2014Article
- The influence of halogen derivatives of thyronine and fluorescein on the dipole potential of phospholipid membranes.The Journal of membrane biology · 2014Article
- Genetic basis of evolutionary adaptation by Escherichia coli to stressful cycles of freezing, thawing and growth.Genetics · 2008Article
- Chain packing in the inverted hexagonal phase of phospholipids: a study by X-ray anomalous diffraction on bromine-labeled chains.Journal of the American Chemical Society · 2006Article
- Hydration and molecular motions in synthetic phytanyl-chained glycolipid vesicle membranes.Biophysical journal · 2001Article
- Dehydration induces lateral expansion of polyunsaturated 18:0-22:6 phosphatidylcholine in a new lamellar phase.Biophysical journal · 2001Article
- Interaction of phloretin with lipid monolayers: relationship between structural changes and dipole potential change.Biophysical journal · 1999Article
- The role of lipids in plastid protein transport.Plant molecular biology · 1998Review
- Hydration of the dienic lipid dioctadecadienoylphosphatidylcholine in the lamellar phase--an infrared linear dichroism and x-ray study on headgroup orientation, water ordering, and bilayer dimensions.Biophysical journal · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diphytanoylphosphatidylcholine (DPhPC) has often been used in the study of protein-lipid interaction and membrane channel activity, because of the general belief that it has high bilayer stability, low ion leakage, and fatty acyl packing comparable to that of phospholipid bilayers in the liquid-crystalline state. In this solid-state 31P and 2H NMR study, we find that the membrane packing geometry and headgroup orientation of DPhPC are highly sensitive to the temperature studied and its water content. The phosphocholine headgroup of DPhPC starts to change its orientation at a water content as high as approximately 16 water molecules per lipid, as evidenced by hydration-dependent 2H NMR study at room temperature. In addition, a temperature-induced structural transition in the headgroup orientation is detected in the temperature range of approximately 20-60 degrees C for lipids with approximately 8-11 water molecules per DPhPC. Dehydration of the lipid by one more water molecule leads to a nonlamellar, presumably cubic, phase formation. The lipid packing becomes a hexagonal phase at approximately 6 water molecules per lipid. A phase diagram of DPhPC in the temperature range of -40 degrees C to 80 degrees C is thus constructed on the basis of NMR results. The newly observed hydration-dependent DPhPC lipid polymorphism emphasizes the importance of molecular packing in the headgroup region in modulating membrane structure and protein-induced pore formation of the DPhPC bilayer.
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