ArticleBiophysical journal1997
Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Gap Junction Channel Regulation: A Tale of Two Gates-Voltage Sensitivity of the Chemical Gate and Chemical Sensitivity of the Fast Voltage Gate.International journal of molecular sciences · 2024Review
- Four-State Model for Simulating Kinetic and Steady-State Voltage-Dependent Gating of Gap Junctions.Biophysical journal · 2020Article
- Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome.Frontiers in physiology · 2020Review
- Gating of Connexin Channels by transjunctional-voltage: Conformations and models of open and closed states.Biochimica et biophysica acta. Biomembranes · 2018Review
- A structural and functional comparison of gap junction channels composed of connexins and innexins.Developmental neurobiology · 2017Review
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- Neurovascular coupling: a parallel implementation.Frontiers in computational neuroscience · 2015Article
- Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos.Frontiers in physiology · 2014Article
- Dynamic tuning of electrical and chemical synaptic transmission in a network of motion coding retinal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Distribution and functional relevance of connexins in renin-producing cells.Pflugers Archiv : European journal of physiology · 2013Review
- Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy.The Journal of membrane biology · 2012Review
- Gap junctions.Comprehensive Physiology · 2012Review
- Biological and biophysical properties of vascular connexin channels.International review of cell and molecular biology · 2009Review
- Gap junction channels and cardiac impulse propagation.The Journal of membrane biology · 2007Review
- Subconductance states of Cx30 gap junction channels: data from transfected HeLa cells versus data from a mathematical model.Biophysical journal · 2006Article
- Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties.Pflugers Archiv : European journal of physiology · 2004Article
- Conductive and kinetic properties of connexin45 hemichannels expressed in transfected HeLa cells.The Journal of membrane biology · 2004Article
- Gap junction channel gating.Biochimica et biophysica acta · 2004Review
- Is the voltage gate of connexins CO2-sensitive? Cx45 channels and inhibition of calmodulin expression.The Journal of membrane biology · 2003Article
- Coupling asymmetry of heterotypic connexin 45/ connexin 43-EGFP gap junctions: properties of fast and slow gating mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gap junctions composed of connexin-45 (Cx45) homologs from four species, zebrafish, chicken, mouse, and human, were expressed in pairs of Xenopus oocytes. The macroscopic conductance (gj) of all Cx45 junctions was modulated by transjunctional voltage (Vj) and by the inside-outside voltage (Vm), and the modulation was species specific. Although their gating characteristics varied in voltage sensitivity and kinetics, the four Cx45 junctions shared 1) maximum conductance at Vj = 0 and symmetrical gj reduction in response to positive and negative Vj of low amplitude, with little residual conductance; and 2) gj increases in response to simultaneous depolarization of the paired cells. The formation of hybrid channels, comprising Cx45 hemichannels from different species, allowed us to infer that two separate gates exist, one in each hemichannel, and that each Cx45 hemichannel is closed by the negativity of Vj on its cytoplasmic side. Interestingly, the Vm dependence of hybrid channels also suggests the presence of two gates in series, one Vm gate in each hemichannel. Thus the Vj and Vm dependence provides evidence that two independent voltage gates in each Cx45 hemichannel exist, reacting through specific voltage sensors and operating by different mechanisms, properties that have evolved divergently among species.
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