ArticleJournal of gastroenterology1997
Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease.
Article in Journal of gastroenterology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Circulating cell adhesion molecules as biomarkers in inflammatory bowel disease: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- Biomarkers are associated with clinical and endoscopic outcomes with vedolizumab treatment in Crohn's disease.Therapeutic advances in gastroenterology · 2020Article
- Biomarkers Are Associated With Clinical and Endoscopic Outcomes With Vedolizumab Treatment in Ulcerative Colitis.Inflammatory bowel diseases · 2019Article
- The role of adhesion molecules in inflammatory bowel disease in children. Assessment of the possible risk of cardiovascular complications.Przeglad gastroenterologiczny · 2017Article
- Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis.International journal of colorectal disease · 2013Article
- Increased plasma sVCAM-1 is associated with severity in IgA nephropathy.BMC nephrology · 2013Article
- L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide.Antimicrobial agents and chemotherapy · 2012Article
- Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease.PloS one · 2009Article
- Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease.Journal of gastroenterology · 2007Review
- Article
- Adhesion molecules in chronic ulcerative colitis.International journal of colorectal disease · 2007Article
- Soluble selectins, sICAM, sVCAM, and angiogenic proteins in different activity groups of patients with inflammatory bowel disease.Digestive diseases and sciences · 2004Article
- Article
- The influence of tobacco smoking on adhesion molecule profiles.Tobacco induced diseases · 2002Article
- Quantification of mucosal leucocyte endothelial cell interaction by in vivo fluorescence microscopy in experimental colitis in mice.Clinical and experimental immunology · 2001Article
- Increased levels of circulating ICAM-1, E-selectin, and IL-2 receptors in celiac disease.Digestive diseases and sciences · 2000Article
- Soluble adhesion molecules in inflammatory bowel disease.Irish journal of medical scienceArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion molecules mediate the extravasation of leukocytes and their accumulation in inflamed tissues. In the present study, serum concentrations of the selectin (sP- and sE-selectin) and immunoglobulin supergene family (sICAM-1 and sVCAM-1) of adhesion molecules were measured in 93 patients with inflammatory bowel disease (Crohn's disease, n = 65; ulcerative colitis, n = 28) and 58 age-matched normal controls. sP-selectin serum concentrations (mean +/- SEM ng/ml) of patients with Crohn's disease (399 +/- 33 ng/ml) and ulcerative colitis (385 +/- 42 ng/ml) were increased (P = 0.0067 and P = 0.0193, respectively) compared to controls (251 +/- 33 ng/ml). In contrast, E-selectin serum levels of patients with Crohn's disease (58 +/- 5 ng/ml) and ulcerative colitis (64 +/- 12 ng/ml) were not significantly higher than those of controls (53 +/- 5 ng/ml). sICAM-1 serum concentrations of patients with Crohn's disease (420 +/- 19 ng/ml) and those with ulcerative colitis (375 +/- 40 ng/ml) were elevated (P = 0.0001 and P = 0.0473, respectively) compared to controls (297 +/- 8 ng/ml). Further, sVCAM-1 levels of patients with Crohn's disease (664 +/- 43 ng/ml) and ulcerative colitis (963 +/- 162 ng/ml) were increased (P = 0.0222 and P = 0.0121, respectively) compared to controls (510 +/- 31 ng/ml). With few exceptions, serum levels of soluble adhesion molecules were not significantly correlated to disease activity indices or disease localization. Elevated circulating selectin and immunoglobulin supergene type adhesion molecules may compete with membrane-bound forms for their cognate ligands and thereby limit the rolling and stable adhesion of leukocytes.
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Registered trials
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