ArticleThe EMBO journal1997
MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Identification and Characterization ofBiomolecules · 2023Article
- SGK regulates pH increase and cyclin B-Cdk1 activation to resume meiosis in starfish ovarian oocytes.The Journal of cell biology · 2019Article
- Quiescent Cells Actively Replenish CENP-A Nucleosomes to Maintain Centromere Identity and Proliferative Potential.Developmental cell · 2019Article
- MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Functional specialization of chordate CDK1 paralogs during oogenic meiosis.Cell cycle (Georgetown, Tex.) · 2015Article
- Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation.Nucleic acids research · 2012Article
- Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor.Nature communications · 2012Article
- MEK inhibition potentiates the activity of Hsp90 inhibitor 17-AAG against pancreatic cancer cells.Molecular pharmaceutics · 2010Article
- Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Induction of apoptosis in starfish eggs requires spontaneous inactivation of MAPK (extracellular signal-regulated kinase) followed by activation of p38MAPK.Molecular biology of the cell · 2004Article
- The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.The EMBO journal · 2002Article
- Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.The EMBO journal · 2002Article
- c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mos activates MAP kinase in mouse oocytes through two opposite pathways.The EMBO journal · 2000Article
- Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes.The EMBO journal · 2000Article
- Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E.The Journal of cell biology · 1998Article
- Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.Molecular biology of the cell · 1998Article
- MAPK inactivation is required for the G2 to M-phase transition of the first mitotic cell cycle.The EMBO journal · 1997Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism by which fertilization initiates S-phase in the zygote is examined by manipulating the activity of MAP kinase in mature starfish eggs. These unfertilized eggs, which are arrested at G1-phase after the completion of meiosis, have high MAP kinase activity but undetectable cdc2 kinase activity. Either fertilization or inhibition of protein synthesis causes a decrease in MAP kinase activity, which is followed by DNA synthesis. Inactivation of MAP kinase with its specific phosphatase, CL100, initiates DNA synthesis in the absence of fertilization, while constitutive activation of MAP kinase with MEK represses the initiation of DNA synthesis following fertilization. Thus, in unfertilized mature starfish eggs, a capacity for DNA replication is already acquired, but entry into S-phase is negatively regulated by MAP kinase activity that is supported by a continuously synthesized protein(s) but not by cdc2 kinase. Upon fertilization, downregulation of MAP kinase activity is necessary and sufficient for triggering the G1/S-phase transition.
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