ArticleThe American journal of pathology1997
Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 84 citations in OpenAlex.
- Hypoxia-induced nitric oxide release by luminal cells stimulates proliferation and uPA secretion of myoepithelial cells in a bicellular murine mammary tumor.Journal of cancer research and clinical oncology · 2015Article
- Article
- Macrophage-derived tumor necrosis factor-alpha is an early component of the molecular cascade leading to angiogenesis in response to aortic injury.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung.American journal of physiology. Cell physiology · 2011Article
- TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice.The Journal of clinical investigation · 2009Article
- Dual roles of tumor necrosis factor-alpha receptor-1 in a mouse model of hindlimb ischemia.Vascular medicine (London, England) · 2009Article
- Emerging roles of PAR-1 and PAFR in melanoma metastasis.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2008Article
- Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties.Biomaterials · 2007Article
- Optimization of adenovirus-mediated endothelial nitric oxide synthase delivery in rat hindlimb ischemia.Gene therapy · 2005Article
- Expression of cyclooxygenase-2 and inducible nitric oxide synthase correlates with tumor angiogenesis in endometrial carcinoma.Medical oncology (Northwood, London, England) · 2005Article
- A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice.The Journal of cell biology · 2001Article
- Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The future role of anti-tumour necrosis factor (TNF) products in the treatment of rheumatoid arthritis.Drugs · 1998Review
- Nitric oxide and angiogenesis.Journal of neuro-oncologyReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We evaluated the role of an endogenous production of nitric oxide (NO) in the in vitro migration of endothelial cells and in the in vivo angiogenic response elicited by platelet-activating factor (PAF), tumor necrosis factor-alpha (TNF), and basic fibroblast growth factor (bFGF). The NO synthase inhibitor, N omega-nitro-L-arginine-methyl ester (L-NAME), but not its enantiomer D-NAME, prevented chemotaxis of endothelial cells induced in vitro by PAF and by TNF. The motogenic activity of TNF was also inhibited by WEB 2170, a specific PAF-receptor antagonist. In contrast, chemotaxis induced by bFGF was not prevented by L-NAME or by WEB 2170. Angiogenesis was studied in vivo in a murine model in which Matrigel was used as a vehicle for the delivery of mediators. In this model, the angiogenesis induced by PAF and TNF was inhibited by WEB 2170 and L-NAME but not by D-NAME. In contrast, angiogenesis induced by bFGF was not affected by L-NAME or by WEB 2170. TNF, but not bFGF, induced PAF synthesis within Matrigel. These results suggest that NO mediates the angiogenesis induced by PAF as well as that induced by TNF, which is dependent on the production of PAF. In contrast, the angiogenic effect of bFGF appears to be both PAF and NO independent.
Indexed as
Identifiers
9250168PMC1858000W1543589095What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.