ArticleThe American journal of pathology1997
Role of complement in acute tubulointerstitial injury of rats with aminonucleoside nephrosis.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 110 citations in OpenAlex.
- Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Trial
- Spatial analysis reveals cellular microenvironments and mechanisms of inflammation and injury in acute interstitial nephritis.Nature communications · 2026Article
- Tubulointerstitial inflammation and fibrosis induced by proteinuria: fresh insights.Frontiers in pharmacology · 2026Review
- Crosstalk between glomeruli and tubules.Nature reviews. Nephrology · 2025Review
- Apical tubular complement activation and the loss of kidney function in proteinuric kidney diseases.Clinical kidney journal · 2024Review
- Filtration and tubular handling of EWE-hC3Nb1, a complement inhibitor nanobody, in wild type mice and a mouse model of proteinuric kidney disease.FEBS open bio · 2024Article
- IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis.CEN case reports · 2023Article
- Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes.Diabetes care · 2018Article
- Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets.American journal of physiology. Renal physiology · 2017Review
- Glomerular disease: Immunosuppressant-induced reduction of proteinuria in IgAN.Nature reviews. Nephrology · 2016Article
- C5b-9 does not mediate tubulointerstitial injury in experimental acute glomerular disease characterized by selective proteinuria.World journal of nephrology · 2016Article
- The Expression Profile of Complement Components in Podocytes.International journal of molecular sciences · 2016Article
- Activation of complement system in kidney after ketoprofen-induced kidney injury in sheep.Acta veterinaria Scandinavica · 2015Article
- Complement activation in progressive renal disease.World journal of nephrology · 2015Review
- Association of Acute Interstitial Nephritis with Carnivora, a Venus Flytrap Extract, in a 30-Year-Old Man with Hodgkin's Lymphoma.Case reports in nephrology · 2014Article
- Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications.Journal of translational medicine · 2011Review
- C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy.Journal of the American Society of Nephrology : JASN · 2009Article
- Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury.Journal of the American Society of Nephrology : JASN · 2008Article
- A protein toxin from the sea anemone Phyllodiscus semoni targets the kidney and causes a severe renal injury with predominant glomerular endothelial damage.The American journal of pathology · 2007Article
- The membrane attack complex, C5b-9, up regulates collagen gene expression in renal tubular epithelial cells.Clinical and experimental immunology · 2004Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present work was designed to elucidate the in vivo role of complement in the proteinuria-associated tubulointerstitial injury. Rats were intravenously injected with puromycin aminonucleoside, and massive proteinuria was observed within 5 days. Prominent tubulointerstitial injury characterized by proximal tubular degeneration, tubular dilatation, and leukocyte infiltration were observed 7 days after injection. C3 and C5b-9 were observed in the luminal side of proximal tubular cells. Renal function, assessed by inulin and para-aminohippurate clearance, was significantly decreased. To-assess the role of complement in this model, rats were injected with either cobra venom factor or soluble recombinant human complement receptor type 1 starting at day 3. These manipulations significantly improved tubulointerstitial pathology and para-aminohippurate clearance without affecting the degree of proteinuria. Deposition of C3 and C5b-9 was not detected in the kidney of rats depleted of complement by cobra venom factor. In rats treated with soluble complement receptor, C3 was still detected in the tubules, but deposition of C5b-9 was not observed. Soluble complement receptor was detected at the site of C3 deposition and in the urine. These data strongly suggest that complement plays a pivotal role in proteinuria-associated tubulointerstitial injury and that systemic complement depletion or inhibition of complement in the tubular lumen may diminish the tubulointerstitial damage.
Indexed as
Identifiers
9250166PMC1857997W1627994195What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.