ArticleThe American journal of pathology1997
Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
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- A Complementary Herbal Product for Controlling Giardiasis.Antibiotics (Basel, Switzerland) · 2021Article
- Therapeutic and nutraceutical potentials of a brown seaweedFood science & nutrition · 2020Review
- The elusive case of human intraepithelial T cells in gut homeostasis and inflammation.Nature reviews. Gastroenterology & hepatology · 2018Review
- Moderate physical exercise reduces parasitaemia and protects colonic myenteric neurons in mice infected with Trypanosoma cruzi.International journal of experimental pathology · 2013Article
- IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice.Mucosal immunology · 2012Article
- Intraepithelial lymphocytes, goblet cells and VIP-IR submucosal neurons of jejunum rats infected with Toxoplasma gondii.International journal of experimental pathology · 2012Article
- Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.Current opinion in HIV and AIDS · 2010Review
- Review
- Staphylococcal enterotoxin B induces potent cytotoxic activity by intraepithelial lymphocytes.Immunology · 2000Article
- Cytolytic mechanisms of intraepithelial lymphocytes in coeliac disease (CoD).Clinical and experimental immunology · 2000Article
- High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.The American journal of pathology · 1999Article
- Functional expression of Fas and Fas ligand on human intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 1999Article
- Most CD56+ intestinal lymphomas are CD8+CD5-T-cell lymphomas of monomorphic small to medium size histology.The American journal of pathology · 1998Article
- Tumour necrosis factor-alpha enhances intraepithelial lymphocyte proliferation and migration.Gut · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Human small intestine contains a very large population of intraepithelial T lymphocytes (IELs) that are oligoclonal, appear functionally to be cytolytic T cells, and may contribute to the normal and pathological turnover of intestinal epithelial cells. This report addresses the cytolytic function of IELs in normal small intestine by examining their expression of molecules that carry out cell-mediated cytolysis. Immunohistochemical analyses of granzyme B, perforin, Fas ligand, and tumor necrosis factor-alpha demonstrated these proteins were not expressed by small intestinal IELs in situ. These proteins also were not expressed by colonic IELs or by lamina propria lymphocytes in the small or large intestine. Granzyme A, however, was expressed by a large fraction of IELs. In contrast to these in situ results, isolated and in vitro activated IELs were shown to express effector proteins consistent with cytolytic T cells, including granzyme B, Fas ligand, tumor necrosis factor-alpha, and interferon-gamma. These results are most consistent with the vast majority of IELs in normal human small intestine being resting cytolytic T cells and suggest that these cells do not contribute to the apoptotic cell death of epithelial cells in normal intestine.
Indexed as
Identifiers
9250156PMC1858008W1595858888What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.