Evidence map›Paper›PMID 9248745›Full record

GuidelineEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology1997

Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. British Society for Medical Mycology.

D W Denning, E G Evans, C C Kibbler, M D Richardson, M M Roberts, T R Rogers, D W Warnock, R E Warren

Abstract readGuidelinePractice Guideline
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In one paragraph

Guideline in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 165 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Review
  6. Aspergillus fumigatus and related species.Cold Spring Harbor perspectives in medicine · 2014
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Forward Modeling of the Coumarin Antifungals; SPR/SAR Based Perspective.Avicenna journal of medical biotechnology · 2009
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

D W DenningDepartment of Infectious Diseases and Tropical Medicine (Monsall Unit), North manchester General Hospital, UK.
E G Evans
C C Kibbler
M D Richardson
M M Roberts
T R Rogers
D W Warnock
R E Warren
North Manchester General Hospital · GBRoyal Shrewsbury Hospital · GBRoyal Victoria Hospital · GBSalford Royal Hospital · GBThe Royal Free Hospital · GBUniversity of Glasgow · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive fungal infections are increasing in incidence and now affect as many as 50% of neutropenic/bone marrow transplant patients and 5 to 20% of solid organ transplant recipients. Unfortunately, many of the diagnostic tests available have a low sensitivity. The guidelines presented here have been produced by a working party of the British Society for Medical Mycology in an attempt to optimise the use of these tests. The yield of fungi from blood cultures can be increased by ensuring that at least 20 ml of blood are taken for aerobic culture, by using more than one method of blood culture, and by employing terminal subculture if continuous monitoring systems are used with a five-day incubation protocol. Skin lesions in febrile neutropenic patients should be biopsied and cultured for fungi. The detection of galactomannan in blood or urine is of value in diagnosing invasive aspergillosis only if tests are performed at least twice weekly in high-risk patients. Antigen detection tests for invasive candidiasis are less valuable. Computed tomography scanning is particularly valuable in diagnosing invasive pulmonary fungal infection when the chest radiograph is negative or shows only minimal changes. Bronchoalveolar lavage is most useful in patients with diffuse changes on computed tomography scan. The major advances in the diagnosis of invasive fungal infection in patients with haematological malignancy or solid organ transplantation have been in the use of imaging techniques, rather than in the development of new mycological methods in the routine laboratory.

Indexed as

Organ TransplantationAlgorithmsCentral Nervous System DiseasesFever of Unknown OriginHematologic NeoplasmsHumansImmunocompromised HostIncidenceLung Diseases, FungalMycosesNasopharyngeal DiseasesNeutropeniaUrinary Tract Infections

Identifiers

PMID9248745
OpenAlexW2022130194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.