ArticleThorax1997
Effect of exposure to swine dust on levels of IL-8 in airway lavage fluid.
Article in Thorax, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 113 citations in OpenAlex.
- Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust.Respiratory research · 2005Trial
- Influence of fluticasone and salmeterol on airway effects of inhaled organic dust;an in vivo and ex vivo study.Clinical and experimental immunology · 2000Trial
- Aryl hydrocarbon receptor (AhR) regulates organic dust and organic dust-associated bacterial extracellular vesicles-induced airway inflammation via ROS-dependent NFκB and STAT3 activation.Respiratory research · 2026Article
- Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation.FASEB bioAdvances · 2025Article
- Assessment of the circulating inflammatory mediator interleukin-8 in dogs with tracheal collapse.The Canadian veterinary journal = La revue veterinaire canadienne · 2024Article
- Organic Dust Exposure Enhances SARS-CoV-2 Entry in a PKCInternational journal of translational medicine (Basel, Switzerland) · 2024Article
- Intranasal and Serum Gentamicin Concentration: Comparison of Three Topical Administration Protocols in Dogs.Veterinary sciences · 2023Article
- Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung inflammatory mediators.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA).International journal of molecular sciences · 2023Article
- Bacterial extracellular vesicles isolated from organic dust induce neutrophilic inflammation in the lung.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Livestock farm particulate matter enhances airway inflammation in mice with or without allergic airway disease.The World Allergy Organization journal · 2020Article
- Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116.PloS one · 2018Article
- Cohort profile: the Saskatchewan Rural Health Study-adult component.BMC research notes · 2017Article
- Effect of low-level COJournal of occupational medicine and toxicology (London, England) · 2017Article
- Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells.Respiratory research · 2016Article
- β2-Adrenergic agonists attenuate organic dust-induced lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Gene expression profiling of the effects of organic dust in lung epithelial and THP-1 cells reveals inductive effects on inflammatory and immune response genes.Physiological genomics · 2016Article
- Industrial Food Animal Production and Community Health.Current environmental health reports · 2015Review
- Transcriptional mechanisms and protein kinase signaling mediate organic dust induction of IL-8 expression in lung epithelial and THP-1 cells.American journal of physiology. Lung cellular and molecular physiology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInhalation of swine dust causes airway inflammation with influx of inflammatory cells, predominantly neutrophils, into the lungs. A study was undertaken to determine whether or not exposure to swine dust induces release of interleukin 8 (IL-8) into upper and lower airways and how this possible release is related to cellular influx. A further aim was to study the relationship between the inflammatory response and swine dust exposure.
methodsThirty one healthy, non-smoking, previously unexposed subjects were exposed to swine dust during three hours work in a swine house. Bronchoalveolar lavage (BAL) was performed two weeks before and 24 hours after the exposure (n = 16). Nasal lavage and acoustic rhinometry were carried out 1-2 hours before and seven hours after the start of the exposure (n = 31). Exposure measurements were performed with personal sampling equipment.
resultsThe exposure led to 19-fold and 70-fold increases in the neutrophil concentrations in nasal lavage and BAL fluid, respectively (p < 0.001). In BAL, fluid macrophages, lymphocytes and eosinophils increased significantly. The IL-8 levels in BAL fluid increased from < 31.3 ng/l to 63 (43-109) ng/l (median (25-75th percentile), p < 0.001), and in nasal lavage fluid the concentrations increased from 144 (97-227) ng/l to 1064 (864-1437) ng/l (p < 0.001). IL-8 levels showed a significant correlation with the increase in neutrophils in the nasal lavage fluid but not in the BAL fluid. Acoustic rhinometry demonstrated significant swelling of the nasal mucosa. The air concentration of inhalable dust was 23.3 (20.0-29.3) mg/m3, endotoxin 1.3 (1.1-1.4) micrograms/m3, and muramic acid 0.99 (0.78-2.1) microgram/m3.
conclusionsThe concentration of IL-8 increases in BAL fluid and nasal lavage fluid following exposure to swine dust and may be one of the chemoattractants contributing to the recruitment of neutrophils to the nasal cavity and the alveolar space.
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Registered trials
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