ArticleAmerican journal of human genetics1997
XIST expression in human oocytes and preimplantation embryos.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 105 citations in OpenAlex.
- X chromosome inactivation in mammals: general principles and species-specific considerations.EMBO reports · 2025Review
- The Expression Pattern and Functional Analysis of Extracellular Vesicle Long Non-Coding RNAs from Uterine Fluid During Implantation in Pig.Animals : an open access journal from MDPI · 2025Article
- Gene regulation in time and space during X-chromosome inactivation.Nature reviews. Molecular cell biology · 2022Review
- LncRNA XIST Prevents Tendon Adhesion and Promotes Tendon Repair Through the miR-26a-5p/COX2 Pathway.Molecular biotechnology · 2022Article
- An improved method for specific-target preamplification PCR analysis of single blastocysts useful for embryo sexing and high-throughput gene expression analysis.Journal of dairy science · 2021Article
- A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans.Nature communications · 2019Article
- RNA-seq as a tool for evaluating human embryo competence.Genome research · 2019Article
- DNA methylation and functional characterization of the XIST gene duringEpigenetics · 2019Article
- Determination of single embryo sex in Macaca mulatta and Mus musculus RNA-Seq transcriptome profiles.Physiological genomics · 2018Article
- Single-Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells.Stem cells (Dayton, Ohio) · 2015Article
- Totipotency: what it is and what it is not.Stem cells and development · 2014Article
- Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome.Stem cells (Dayton, Ohio) · 2012Review
- XCI in preimplantation mouse and human embryos: first there is remodelling….Human genetics · 2011Review
- The single active X in human cells: evolutionary tinkering personified.Human genetics · 2011Review
- Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos.PloS one · 2011Article
- A comparative genome analysis of gene expression reveals different regulatory mechanisms between mouse and human embryo pre-implantation development.Reproductive biology and endocrinology : RB&E · 2010Article
- X chromosome inactivation is initiated in human preimplantation embryos.American journal of human genetics · 2009Article
- Lessons from comparative analysis of X-chromosome inactivation in mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Review
- Genomic imprinting mechanisms in mammals.Mutation research · 2008Review
- X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected.Journal of cellular physiology · 2008Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mouse preimplantation development, the exclusive expression of the Xist gene from the paternally inherited allele is thought to play a role in the inactivation of the paternally inherited X chromosome in the extra-embryonic cell lineages of the developing female embryo. Recently, inactivation of the paternally inherited X chromosome has also been shown to occur in the extraembryonic cell lineages of the human female conceptus. In this paper, we determine whether the pattern of XIST expression in human preimplantation embryos is similarly correlated with paternal X inactivation. We developed procedures sensitive to the single cell, for the simultaneous analysis of XIST and HPRT expression and of sexing, initially using human fibroblast cells. Application of these procedures to human cleavage-stage embryos derived by in vitro fertilization revealed a pattern of XIST expression different from that in the mouse. Transcripts of the XIST gene were detected as early as the 1-cell zygote and, with increasing efficiency, through to the 8-cell stage of preimplantation development. In addition, transcripts of XIST were detected in both male (hence from the maternally inherited allele) and female preimplantation embryos. This pattern of expression is not consistent with a role for the early expression of the XIST gene in the choice of paternal X inactivation in the extraembryonic cell lineages of the developing human embryo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.