ArticleAmerican journal of human genetics1997
First-meiotic-division nondisjunction in human oocytes.
Article in American journal of human genetics, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 300 citations in OpenAlex.
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Chromosome architecture and low cohesion bias acrocentric chromosomes towards aneuploidy during mammalian meiosis.Nature communications · 2024Article
- Oocyte Health and Quality: Implication of Mitochondria-related Organelle Interactions.Results and problems in cell differentiation · 2024Review
- Spindle assembly checkpoint insensitivity allows meiosis-II despite chromosomal defects in aged eggs.EMBO reports · 2023Article
- Actin limits egg aneuploidies associated with female reproductive aging.Science advances · 2023Article
- Development and application of a computable genotype model in the GA4GH Variation Representation Specification.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
- Article
- Genome diversity and instability in human germ cells and preimplantation embryos.Seminars in cell & developmental biology · 2021Article
- Article
- Mathematical modeling of human oocyte aneuploidy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Some of the Factors Involved in Male Infertility: A Prospective Review.International journal of general medicine · 2020Review
- How common is germinal mosaicism that leads to premeiotic aneuploidy in the female?Journal of assisted reproduction and genetics · 2019Review
- Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs.Current biology : CB · 2019Article
- Can cytoplasmic donation rescue aged oocytes?Reproductive medicine and biology · 2019Review
- Epigenetics and Female Reproductive Aging.Frontiers in endocrinology · 2019Review
- Using Fluorescence In Situ Hybridization (FISH) to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes.Journal of visualized experiments : JoVE · 2017Article
- Haspin inhibition reveals functional differences of interchromatid axis-localized AURKB and AURKC.Molecular biology of the cell · 2017Article
- Merotelic kinetochore attachment in oocyte meiosis II causes sister chromatids segregation errors in aged mice.Cell cycle (Georgetown, Tex.) · 2017Article
- Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.Nature communications · 2017Article
- Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Reject oocytes from in vitro-fertilization patients are currently the only practical source of human oocyte material available for meiotic studies in women. Two hundred clearly analyzable second meiotic (MII) metaphase oocytes from 116 patients were examined for evidence of first meiotic (MI) division errors. The chromosome results, in which 67% of oocytes had a normal 23,X chromosome complement but none had an extra whole chromosome, cast doubt on the relevance, to human oocytes, of those theories of nondisjunction that propose that both chromosomes of the bivalent fail to disjoin at MI so that both move to one pole and result in an additional whole chromosome at MII metaphase. The only class of abnormality found in the MII oocytes had single chromatids (half-chromosomes) replacing whole chromosomes. Analysis of the chromosomally abnormal oocytes revealed an extremely close correlation with data on trisomies in spontaneous abortions, with respect to chromosome distribution, frequency, and maternal age, and indicated the likelihood of the chromatid abnormalities being the MI-division nondisjunction products that lead to trisomy formation after fertilization. The most likely derivation of the abnormalities is through a from of misdivision process usually associated with univalents, in which the centromeres divide precociously at MI, instead of MII, division. In the light of recent data that show that altered recombination patterns of the affected chromosomes are a key feature of most MI-division trisomies, the oocyte data imply that the vulnerable meiotic configurations arising from altered recombination patterns are processed as functional univalents in older women. Preliminary evidence from MI-metaphase oocytes supports this view.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.