ArticleGut1997
Short segment Barrett's oesophagus: prevalence, diagnosis and associations.
Article in Gut, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Helicobacter pylori infection reduces the risk of Barrett's esophagus: A meta-analysis and systematic review.Helicobacter · 2018Pooled it
- The association between Barrett's esophagus and Helicobacter pylori infection: a meta-analysis.Helicobacter · 2012Pooled it
- Barrett's esophagus around the world: a systematic review and predictive modeling study.Gastroenterology and hepatology from bed to bench · 2026Review
- Mechanisms and pathophysiology of Barrett oesophagus.Nature reviews. Gastroenterology & hepatology · 2022Review
- The prevalence ofGut pathogens · 2018Article
- Utility of endoscopy for diagnosis of barrett in a non-Western society: endoscopic and histopathologic correlation.International surgery · 2015Article
- Prevalence of Barrett's esophagus in patients with or without GERD symptoms: role of race, age, and gender.Digestive diseases and sciences · 2009Article
- Can Western endoscopists identify the end of the lower esophageal palisade vessels as a landmark of esophagogastric junction?Journal of gastroenterology · 2009Article
- Barrett's columnar-lined oesophagus: demographic and lifestyle associations and adenocarcinoma risk.Digestive diseases and sciences · 2008Article
- Short-Segment Barrett's Esophagus and Adenocarcinoma.Gastroenterology & hepatology · 2006Article
- Increased Barrett's esophagus for the decade between 1991 and 2000 at a single university medical center.Digestive diseases and sciences · 2005Article
- Article
- [Correct diagnosis for indication in gastroesophageal reflux disease].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2005Review
- Review
- Barrett's oesophagus and adenocarcinoma.World journal of surgical oncology · 2004Article
- Article
- Barrett's esophagus: environmental influences in the progression of dysplasia.World journal of surgery · 2003Review
- Role of surveillance in intestinal metaplasia of the esophagus and gastroesophageal junction.World journal of surgery · 2003Review
- Effect of Helicobacter pylori infection in Barrett's esophagus and the genesis of esophageal adenocarcinoma.World journal of surgery · 2003Review
- Trends in incidence and prevalence of specialized intestinal metaplasia, barrett's esophagus, and adenocarcinoma of the gastroesophageal junction.World journal of surgery · 2003Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevalence of short segment Barrett's (SSB) oesophagus, defined as the absence of macroscopic Barrett's but histologically identifiable intestinal metaplasia, has been reported to be 18% based on haematoxylin and eosin (H&E) staining.
aimsTo define the prevalence of SSB oesophagus using H&E and alcian blue staining and to determine whether SSB oesophagus is associated with inflammation at the gastro-oesophageal junction (GOJ). SUBJECTS: Consecutive patients (n = 158) presenting for endoscopy completed a structured interview.
methodsTwo biopsy specimens taken from the GOJ were stained with H&E, alcian blue and Giemsa. A third specimen was obtained from the distal oesophagus. Intestinal metaplasia was diagnosed if goblet cells were definitely identified by two independent observers.
resultsSSB oesophagus was present in 46 (prevalence 36%, 95% confidence interval (CI) 28.5-43.5) using alcian blue staining. If H&E had been the sole staining method used, 50% cases of intestinal metaplasia would have been overlooked. There were no cases of intestinal metaplasia identified by H&E but missed by alcian blue staining. Logistic regression analysis identified age (odds ratio (OR) per decade 1.03, 95% CI 1.01-1.06), histological oesophagitis (OR 3.2, 95% CI 1.4-7.2) and inflammation at the gastrooesophageal junction (OR 5.9, 95% CI 2.2-15.6) as independent risk factors for SSB oesophagus.
conclusionUnrecognised SSB oesophagus is highly prevalent in patients presenting for diagnostic upper endoscopy if alcian blue staining is applied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.