ReviewPharmaceutical research1997
Cationic lipid-based gene delivery systems: pharmaceutical perspectives.
Review in Pharmaceutical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 214 citations in OpenAlex.
- Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential.Molecular biology reports · 2025Review
- An emerging era in manufacturing of drug delivery systems: Nanofabrication techniques.Heliyon · 2023Review
- Gene Therapy for Acute Respiratory Distress Syndrome.Frontiers in physiology · 2021Review
- The Convergence of Cell-Based Surface Plasmon Resonance and Biomaterials: The Future of Quantifying Bio-molecular Interactions-A Review.Annals of biomedical engineering · 2020Review
- Synthesis and Evaluation of pH-Sensitive Multifunctional Lipids for Efficient Delivery of CRISPR/Cas9 in Gene Editing.Bioconjugate chemistry · 2019Article
- Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery.Pharmaceutics · 2019Review
- Antiviral effects of hepatitis B virus S gene-specific anti-gene locked nucleic acid in transgenic mice.World journal of clinical cases · 2018Article
- Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells.Journal of visualized experiments : JoVE · 2015Article
- 2-diethylaminoethyl-dextran methyl methacrylate copolymer nonviral vector: still a long way toward the safety of aerosol gene therapy.Gene therapy · 2013Article
- Mechanisms of action underlying the immunotherapeutic activity of Allovectin in advanced melanoma.Cancer gene therapy · 2012Review
- RGD peptide-modified adenovirus expressing hepatocyte growth factor and X-linked inhibitor of apoptosis improves islet transplantation.The journal of gene medicine · 2011Article
- Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation.Bioconjugate chemistry · 2010Article
- Lipid and polymeric carrier-mediated nucleic acid delivery.Expert opinion on drug delivery · 2010Review
- Synergistic effects of surfactants and sugars on lipoplex stability during freeze-drying and rehydration.Journal of pharmaceutical sciences · 2009Article
- Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity.Bioconjugate chemistry · 2009Article
- Effects of moisture content on the storage stability of dried lipoplex formulations.Journal of pharmaceutical sciences · 2009Article
- Polycationic triazine-based dendrimers: effect of peripheral groups on transfection efficiency.New journal of chemistry = Nouveau journal de chimie · 2009Article
- Structural and formulation factors influencing pyridinium lipid-based gene transfer.Bioconjugate chemistry · 2008Article
- Chemical activation of lipoplexes formed from DNA and a redox-active, ferrocene-containing cationic lipid.Bioconjugate chemistry · 2008Article
- Site-specific delivery of oligonucleotides to hepatocytes after systemic administration.Bioconjugate chemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene delivery systems are designed to control the location of administered therapeutic genes within a patient's body. Successful in vivo gene transfer may require (i) the condensation of plasmid and its protection from nuclease degradation, (ii) cellular interaction and internalization of condensed plasmid, (iii) escape of plasmid from endosomes (if endocytosis is involved), and (iv) plasmid entry into cell nuclei. Expression plasmids encoding a therapeutic protein can be, for instance, complexed with cationic liposomes or micelles in order to achieve effective in vivo gene transfer. A thorough knowledge of pharmaceutics and drug delivery, bio-engineering, as well as cell and molecular biology is required to design optimal systems for gene therapy. This mini-review provides a critical discussion on cationic lipid-based gene delivery systems and their possible uses as pharmaceuticals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.