Evidence map›Paper›PMID 9239754›Full record

ArticleNeurochemical research1997

Constitutive expression of calmodulin-binding phosphoprotein GAP-43 in rat serotonergic and noradrenergic cell groups which project to the spinal cord.

G Wotherspoon, J J López-Costa, G J Michael, J V Priestley

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Protocadherin-alpha family is required for serotonergic projections to appropriately innervate target brain areas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009
    Article
  2. Article
  3. GAP-43 is critical for normal development of the serotonergic innervation in forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

G WotherspoonDepartment of Anatomy, Faculty of Basic Medical Sciences, Queen Mary and Westfield College, London.
J J López-Costa
G J Michael
J V Priestley
Queen Mary University of London · GBUniversity of Buenos Aires · AR

Funding

Wellcome Trust
6 · The paper itself

Abstract

In situ hybridization was combined with serotonin (5-hydroxytryptamine, 5-HT) or tyrosine hydroxylase immunocytochemistry and with Fluoro-Gold retrograde labeling of bulbo-spinal pathways in order to investigate the expression of GAP-43 mRNA in monoamine cell groups of the adult rat brain stem. Consistent with previous reports, GAP-43 mRNA was observed in serotonin and dopamine cell groups in the pons. In addition, GAP-43 expressing cells were observed in all the major monoamine cell groups in the medulla. Thus the B1, B2 and B3 serotonin cell groups all showed high GAP-43 expression in all contained many GAP-43 expressing serotonin cells with spinal cord projections. The A1, A2, A5 and A6 noradrenaline cell groups also showed high GAP-43 expression, although cells with spinal cord projections were largely restricted to the A5 group and A6 subcoeruleus region. In all areas, GAP-43 expressing cells with spinal cord projections were also observed which were not serotonergic or noradrenergic.

Indexed as

AnimalsBrain StemCalmodulin-Binding ProteinsDopamineFluorescent Antibody TechniqueGAP-43 ProteinIn Situ Hybridization, FluorescenceMaleMedulla OblongataMembrane GlycoproteinsNerve Tissue ProteinsNorepinephrineOligonucleotide ProbesPonsRatsRats, WistarCalmodulin-Binding ProteinsDopamineGAP-43 ProteinMembrane GlycoproteinsNerve Tissue ProteinsNorepinephrineOligonucleotide ProbesRNA, MessengerSerotoninTyrosine 3-Monooxygenase

Identifiers

PMID9239754
OpenAlexW313379935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.