ReviewNeurochemical research1997
The role of axonal cytoskeleton in diabetic neuropathy.
Review in Neurochemical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Microtubule Cytoskeleton Dysfunction in Chronic Pain: Mechanisms of Transport Failure and Emerging Therapeutic Targets.International journal of molecular sciences · 2026Review
- Effects of Aerobic and Interval Training on Peripheral Nerve Recovery in Male and Female Diabetic Rats.Cureus · 2025Article
- Deciphering the Tubulin Language: Molecular Determinants and Readout Mechanisms of the Tubulin Code in Neurons.International journal of molecular sciences · 2023Review
- Role of tubulin post-translational modifications in peripheral neuropathy.Experimental neurology · 2023Review
- Axonal transport deficits in the pathogenesis of diabetic peripheral neuropathy.Frontiers in endocrinology · 2023Review
- Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network.Oncotarget · 2021Article
- Diabetes Mellitus-Related Dysfunction of the Motor System.International journal of molecular sciences · 2020Review
- Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies.Molecular neurobiology · 2019Review
- Neonatal hyperglycemia induces cell death in the rat brain.Metabolic brain disease · 2018Article
- Mechanisms of distal axonal degeneration in peripheral neuropathies.Neuroscience letters · 2015Review
- Post-translational modifications of tubulin: pathways to functional diversity of microtubules.Trends in cell biology · 2015Review
- Age-dependent slowing of enteric axonal transport in insulin-resistant mice.World journal of gastroenterology · 2013Article
- Probing functional properties of nociceptive axons using a microfluidic culture system.PloS one · 2013Article
- Article
- Down regulation of the proliferation and apoptotic pathways in the embryonic brain of diabetic rats.Cellular and molecular neurobiology · 2012Article
- COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob/ob mice.PloS one · 2012Article
- Phosphoinositide 3-kinase signaling in the vertebrate retina.Journal of lipid research · 2010Review
- Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors.Journal of neurochemistry · 2009Article
- Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor.Chemico-biological interactions · 2009Article
- Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides.Journal of neurochemistry · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropathy associated with diabetes includes well documented impairment of axonal transport, a reduction in axon calibre and a reduced capacity for nerve regeneration. All of those aspects of nerve function rely on the integrity of the axonal cytoskeleton. Alterations in the axonal cytoskeleton in experimental diabetes include an insulin-dependent non-enzymatic glycation of actin that is reflected in increased glycation of platelet actin in the clinical situation. There is a reduced synthesis of mRNA for the isoforms of tubulin that are associated with nerve growth and regeneration and an elevated non-enzymatic glycation of peripheral nerve tubulin in both diabetic patients and diabetic animals. mRNAs for neurofilament proteins are selectively reduced in the diabetic rat and post-translational modification of at least one of the neurofilament proteins is altered. There is some evidence that altered expression of isoforms of protein kinases may contribute to these changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.