ArticleThe Journal of clinical investigation1997
Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 118 citations in OpenAlex.
- The clinical features and potential mechanisms of cognitive disorders in peripheral autoimmune and inflammatory diseases.Fundamental research · 2024Review
- Cognitive Impairment in Anti-Phospholipid Syndrome and Anti-Phospholipid Antibody Carriers.Brain sciences · 2022Review
- Non-Criteria Manifestations of Juvenile Antiphospholipid Syndrome.Journal of clinical medicine · 2021Review
- Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome.Journal of autoimmunity · 2016Article
- Diffusion tensor imaging in patients with obstetric antiphospholipid syndrome without neuropsychiatric symptoms.European radiology · 2016Observational
- Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome.Current rheumatology reports · 2016Review
- Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO)--conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.Molecular psychiatry · 2015Article
- Revisiting the molecular mechanism of neurological manifestations in antiphospholipid syndrome: beyond vascular damage.Journal of immunology research · 2014Review
- Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome.Journal of neural transmission (Vienna, Austria : 1996) · 2013Review
- Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway.Journal of autoimmunity · 2013Article
- Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice.BMC medicine · 2013Article
- Increased anti-phospholipid antibodies in autism spectrum disorders.Mediators of inflammation · 2013Article
- Cognitive impairment in antiphospholipid syndrome: evidence from animal models.Clinical rheumatology · 2012Review
- The pathogenesis of neural injury in animal models of the antiphospholipid syndrome.Clinical reviews in allergy & immunology · 2010Article
- Depression is an early disease manifestation in lupus-prone MRL/lpr mice.Journal of neuroimmunology · 2009Article
- Antiphospholipid antibodies: paradigm in transition.Journal of neuroinflammation · 2009Review
- Neurologic manifestations of the antiphospholipid syndrome: integrating molecular and clinical lessons.Current rheumatology reports · 2008Review
- Antiphospholipid syndrome and vascular ischemic (occlusive) diseases: an overview.Yonsei medical journal · 2007Review
- Mouse model of diffuse brain damage following anoxia, evaluated by a new assay of generalized arousal.Experimental neurology · 2007Article
- Antiphospholipid syndrome and cognition.Clinical reviews in allergy & immunology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiphospholipid antibodies (aPL) have been associated with various neurological manifestations, but the underlying mechanism has not been elucidated. We assessed mice with induced experimental antiphospholipid syndrome (APS) for neurological and behavioral changes. After immunization with monoclonal human anticardiolipin antibody (H-3), female BALB/c mice developed elevated levels of circulating anti-negatively charged phospholipids (aPL), anti-beta2-glycoprotein I (abeta2GPI), and anti-endothelial cell antibodies (AECA), along with clinical manifestations of APS like thrombocytopenia and fetus resorption. APS mice were impaired neurologically and performed several reflexes less accurately compared to the controls, including placing reflex (P < 0.05), postural reflex (P < 0.05), and grip test (P = 0.05). The APS mice also exhibited hyperactive behavior in an open field, which tests spatial behavior (P < 0.03), and displayed impaired motor coordination on a rotating bar. aPL in combination with abeta2GPI and AECA is probably involved in the neurological and behavioral defects shown in mice with experimental APS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.