ArticleProceedings of the National Academy of Sciences of the United States of America1997
Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.Nature communications · 2018Review
- Review
- The fission yeast CENP-B protein Abp1 prevents pervasive transcription of repetitive DNA elements.Biochimica et biophysica acta · 2016Article
- Centromeres of filamentous fungi.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Review
- Article
- The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching.The EMBO journal · 2008Article
- Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals.Molecular biology and evolution · 2008Article
- The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.Cell division · 2006Article
- Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.Current genetics · 2006Article
- E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains.Oncogene · 2004Article
- Kinetochore and heterochromatin domains of the fission yeast centromere.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- Site-specific ORC binding, pre-replication complex assembly and DNA synthesis at Schizosaccharomyces pombe replication origins.The EMBO journal · 2002Article
- Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.Genes & development · 2002Article
- Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B.Genetics · 2001Article
- Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation.Molecular and cellular biology · 2000Article
- Localization and properties of a silencing element near the mat3-M mating-type cassette of Schizosaccharomyces pombe.Genetics · 1999Article
- The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin.Nucleic acids research · 1998Article
- Interspersed centromeric element with a CENP-B box-like motif in Chironomus pallidivittatus.Nucleic acids research · 1998Article
- Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights.The Journal of cell biology · 1998Article
- A helix-turn-helix structure unit in human centromere protein B (CENP-B).The EMBO journal · 1998Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We have purified and characterized a novel 60-kDa protein that binds to centromeric K-type repeat DNA from Schizosaccharomyces pombe. This protein was initially purified by its ability to bind to the autonomously replicating sequence 3002 DNA. Cloning of the gene encoding this protein revealed that it possesses significant homology to the mammalian centromere DNA-binding protein CENP-B and S. pombe Abp1, and this gene was designated as cbh+ (CENP-B homologue). Cbh protein specifically interacts in vitro with the K-type repeat DNA, which is essential for centromere function. The Cbh-binding consensus sequence was determined by DNase I footprinting assays as PyPuATATPyPuTA, featuring an inverted repeat of the first four nucleotides. Based on its binding activity to centromeric DNA and homology to centromere proteins, we suggest that this protein may be a functional homologue of the mammalian CENP-B in S. pombe.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.