ArticleJournal of molecular evolution1997
Sequence diversity and molecular evolution of the merozoite surface antigen 2 of Plasmodium falciparum.
Article in Journal of molecular evolution, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 79 citations in OpenAlex.
- Antibody responses to polymorphic Plasmodium falciparum merozoite antigens in Malawian children with severe and uncomplicated malaria.Malaria journal · 2025Article
- Genetic Diversity and Phylogenetic Relatedness of Cameroonian Plasmodium falciparum Isolates and Comparative Analysis with Global Populations.Acta parasitologica · 2025Article
- Development of high affinity antibodies toFrontiers in immunology · 2025Article
- Genetic polymorphism of merozoite surface proteins 1 and 2 of Plasmodium falciparum in the China-Myanmar border region.Malaria journal · 2019Article
- Article
- Molecular incidence and clearance of Plasmodium falciparum infection.Malaria journal · 2015Article
- Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens.BMC microbiology · 2015Article
- Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains.Malaria journal · 2014Article
- Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Characterization of a novel gene for strain typing reveals substructuring of Aspergillus fumigatus across North America.Eukaryotic cell · 2007Article
- Antigenic diversity and immune evasion by malaria parasites.Clinical and diagnostic laboratory immunology · 2004Review
- Genetic diversity and antigenic polymorphism in Plasmodium falciparum: extensive serological cross-reactivity between allelic variants of merozoite surface protein 2.Infection and immunity · 2003Article
- Meiotic recombination, cross-reactivity, and persistence in Plasmodium falciparum.Evolution; international journal of organic evolution · 2001Article
- Antibody responses to infections with strains of Plasmodium falciparum expressing diverse forms of merozoite surface protein 2.Infection and immunity · 2001Article
- Population structure and recent evolution of Plasmodium falciparum.Proceedings of the National Academy of Sciences of the United States of America · 2000Review
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eleven new alleles of the Plasmodium falciparum merozoite surface antigen 2 (MSA2) from Papua New Guinea were analyzed by direct sequencing of polymerase chain reaction (PCR) products. We have used the sequence information to trace the molecular evolution of MSA2. The repeats of ten alleles belonging to the 3D7 allelic family differed considerably in size, nucleotide sequence, and repeat copy number. In the repeat region of these new alleles, codon usage was extremely biased with an exclusive use of NNT codons. Another new allele sequenced belonged to the FC27 family and confirmed the family-specific conserved structure of 96 and 36 bp repeats. In order to assess sequence microheterogeneity within samples defined as the same genotype by restriction fragment length polymorphism (RFLP), we have analyzed single-strand conformation polymorphism (SSCP) of different samples of the most frequent allele (D10 of the FC27 family) in the study population. No sequence heterogeneity could be detected within the repeat region. Based on analysis of the repeat regions in both allelic families, we discuss the hypothesis of a different evolutionary strategy being represented by each of the allelic families. Kew words: Merozoite surface antigen 2 - Nucleotide sequence comparisons - Molecular evolution
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