ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 90 citations in OpenAlex.
- The Endocannabinoid System in Retinal Müller Glia: Lessons From Astrocyte Research.Neurochemical research · 2025Review
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- Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury.Frontiers in cell and developmental biology · 2021Review
- Spatial control of membrane traffic in neuronal dendrites.Molecular and cellular neurosciences · 2020Review
- Recent Findings on AMPA Receptor Recycling.Frontiers in cellular neuroscience · 2018Review
- The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells.Molecular and cellular neurosciences · 2017Article
- Ablation of TFR1 in Purkinje Cells Inhibits mGlu1 Trafficking and Impairs Motor Coordination, But Not Autistic-Like Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- The cellular mechanisms that maintain neuronal polarity.Nature reviews. Neuroscience · 2016Review
- Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.Scientific reports · 2016Article
- Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons.PLoS pathogens · 2014Article
- Primary cilia and dendritic spines: different but similar signaling compartments.Molecules and cells · 2013Review
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- Temporal manipulation of transferrin-receptor-1-dependent iron uptake identifies a sensitive period in mouse hippocampal neurodevelopment.Hippocampus · 2012Article
- Differential trafficking of transport vesicles contributes to the localization of dendritic proteins.Cell reports · 2012Article
- Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.Molecular and cellular neurosciences · 2011Review
- A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.Molecular biology of the cell · 2011Article
- Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The role of iron in learning and memory.Advances in nutrition (Bethesda, Md.) · 2011Review
- The Sushi domains of GABAB receptors function as axonal targeting signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons are highly polarized cells that must sort proteins synthesized in the cell body for transport into the axon or the dendrites. Given the amount of time and energy needed to deliver proteins to the distal processes, neurons must have high fidelity mechanisms that ensure proper polarized protein trafficking. Although a variety of proteins are localized either to the somatodendritic domain or to the axon (), the question of whether there are signal-dependent mechanisms that sort proteins to distinct neuronal domains is only beginning to be addressed. To determine sequence requirements for the polarized sorting of transmembrane proteins into dendrites, we expressed mutant transferrin receptors in cultured rat hippocampal neurons, using a defective herpes virus vector. Wild-type human transferrin receptor colocalized with the endogenous protein in dendritic endosomes and was strictly excluded from axons, despite overexpression. Polarized targeting was abolished by deletion of cytoplasmic amino acids 7-10, 11-14, or 19-28, but not 29-42 or 43-58. These deletions also increased the appearance of transferrin receptor on the plasma membrane, implying that endocytosis and dendritic targeting are mediated by overlapping signals and similar molecular mechanisms. In addition, we have characterized a specialized para-Golgi endosome poised to play a critical role in the polarized recycling of transmembrane proteins.
Indexed as
Identifiers
9236215PMC6568350W2107517282What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.