ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Small-Molecule Trk Agonists: Where Do We Go from Here?Journal of medicinal chemistry · 2025Review
- Selective Modulation of Trk Receptors byACS chemical neuroscience · 2025Article
- Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa.PNAS nexus · 2025Article
- Selective, Intrinsically Fluorescent Trk Modulating Probes.ACS chemical neuroscience · 2024Article
- A, B, C's of Trk Receptors and Their Ligands in Ocular Repair.International journal of molecular sciences · 2022Review
- Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.PloS one · 2019Article
- The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.PloS one · 2016Article
- A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo.Molecular and cellular biology · 2015Article
- The conundrum of the high-affinity NGF binding site formation unveiled?Biophysical journal · 2015Article
- Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.PloS one · 2014Article
- Comparison of nerve growth factor receptor binding models using heterodimeric muteins.Journal of neuroscience research · 2012Article
- Chronic and acute models of retinal neurodegeneration TrkA activity are neuroprotective whereas p75NTR activity is neurotoxic through a paracrine mechanism.The Journal of biological chemistry · 2010Article
- A monovalent agonist of TrkA tyrosine kinase receptors can be converted into a bivalent antagonist.Biochimica et biophysica acta · 2010Article
- Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo.Cancer chemotherapy and pharmacology · 2010Article
- A peptidomimetic of NT-3 acts as a TrkC antagonist.Peptides · 2009Article
- Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals.ACS chemical biology · 2009Article
- p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Low concentrations of aggregated beta-amyloid induce neurite formation via the neurotrophin receptor p75.Journal of molecular medicine (Berlin, Germany) · 2005Article
- Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling.The Biochemical journal · 2005Article
- Long-lasting rescue of age-associated deficits in cognition and the CNS cholinergic phenotype by a partial agonist peptidomimetic ligand of TrkA.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve growth factor (NGF) receptor-mediated signaling was studied using specific monoclonal antibodies (mAbs) as ligands that discriminate between the receptors TrkA and p75. mAb-induced trophic signals were compared with the signals of the natural ligand NGF. In cells expressing TrkA but no p75 receptors (TrkA+ p75(-)), binding of TrkA with mAb 5C3 leads to optimal signals. In cells expressing both TrkA and p75 (TrkA+ p75(+)), binding of TrkA with mAb 5C3 leads to significant but suboptimal signals, and optimal trophic signals are obtained by concomitant binding of TrkA and p75 with mAbs 5C3 and MC192. In TrkA+ p75(+) cells, binding of anti-p75 mAb MC192 also enhances the trophic effect of suboptimal concentrations of NGF. In contrast, in cells expressing p75 receptors singly (TrkA- p75(+)), binding with mAb MC192 or NGF causes very limited or no trophic effects. Thus, the data support the hypothesis that unbound p75 may modulate TrkA trophic signals. Importantly, the data also demonstrate for the first time that in multireceptor systems appropriate combinations of anti-receptor mAbs can fully mimic the signals of a polypeptide growth factor.
Indexed as
Identifiers
9236214PMC6568372W1671332310What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.