ArticleThe Journal of experimental medicine1997
Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 139 citations in OpenAlex.
- Mechanisms of tumor cell evasion from NK cell-mediated killing and advances in NK cell-based cancer immunotherapy.Pharmaceutical science advances · 2026Review
- Article
- Inducible down-regulation of MHC class I results in natural killer cell tolerance.The Journal of experimental medicine · 2019Article
- Immunopathology of Airway Surface Liquid Dehydration Disease.Journal of immunology research · 2019Review
- Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned.Trends in immunology · 2018Review
- Article
- The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.Frontiers in immunology · 2017Review
- Cognate HLA absence in trans diminishes human NK cell education.The Journal of clinical investigation · 2016Article
- NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions.Nature communications · 2016Article
- Functional Reconstitution of Natural Killer Cells in Allogeneic Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2016Review
- Ionomycin Treatment Renders NK Cells Hyporesponsive.PloS one · 2016Article
- Newtonian cell interactions shape natural killer cell education.Immunological reviews · 2015Review
- SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.Frontiers in immunology · 2015Article
- Impaired NK-cell education diminishes resistance to murine CMV infection.European journal of immunology · 2014Article
- Adaptations of Natural Killer Cells to Self-MHC Class I.Frontiers in immunology · 2014Article
- Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control.Frontiers in immunology · 2014Review
- Viral infection transiently reverses activation receptor-mediated NK cell hyporesponsiveness in an MHC class I-independent mechanism.European journal of immunology · 2013Article
- Controlling natural killer cell responses: integration of signals for activation and inhibition.Annual review of immunology · 2013Review
- Natural killer cell tolerance: control by self or self-control?Cold Spring Harbor perspectives in biology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied natural killer (NK) cell tolerance in a major histocompatibility complex (MHC) class I transgenic line, DL6, in which the transgene product was expressed on only a fraction of blood cells. In contrast with transgenic mice expressing the same transgene in all cells, NK cells from mosaic mice failed to reject transgene-negative bone marrow or lymphoma grafts. However, they retained the capability to reject cells with a total missing-self phenotype, i.e., cells lacking also wild-type MHC class I molecules. Tolerance against transgene-negative cells was demonstrated also in vitro, and could be broken if transgene-positive spleen cells of mosaic mice were separated from negative cells before, or after 4 d of culture in interleukin-2. The results provide support for selective NK cell tolerance to one particular missing-self phenotype but not to another. We suggest that this tolerance is determined by NK cell interactions with multiple cells in the environment, and that it is dominantly controlled by the presence of cells lacking a specific MHC class I ligand. Furthermore, the tolerant NK cells could be reactivated in vitro, which suggests that the tolerance occurs without deletion of the potentially autoreactive NK cell subset(s), and that it may be dependent upon the continuous presence of tolerizing cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.