ArticleInfection and immunity1997
Mice lacking the gamma interferon receptor have an impaired granulomatous reaction to Schistosoma mansoni infection.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Protective efficacy of dapagliflozin against schistosomiasis mansoni-induced liver pathology: an in vivo study.Scientific reports · 2026Article
- Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine levels.PLoS neglected tropical diseases · 2022Article
- Article
- In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars.Mediators of inflammation · 2017Article
- Lack of host gut microbiota alters immune responses and intestinal granuloma formation during schistosomiasis.Clinical and experimental immunology · 2014Article
- The M1 and M2 paradigm of macrophage activation: time for reassessment.F1000prime reports · 2014Review
- Article
- HTLV-1 modifies the clinical and immunological response to schistosomiasis.Clinical and experimental immunology · 2004Article
- Regulation of granulomatous inflammation in experimental models of schistosomiasis.Infection and immunity · 2004Review
- Infections in patients with inherited defects in phagocytic function.Clinical microbiology reviews · 2003Review
- Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Biologic functions of the IFN-gamma receptors.Allergy · 1999Review
- Article
- The immune response modifier imiquimod requires STAT-1 for induction of interferon, interferon-stimulated genes, and interleukin-6.Antimicrobial agents and chemotherapy · 1999Article
- Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis mansoni-infected mice.Immunology · 1998Article
- Immunopathology of schistosomiasis.Immunology and cell biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The egg-induced granulomatous reaction in Schistosoma mansoni-infected individuals develops within the portal system of the liver and is the major pathological finding in schistosomiasis. We have infected mice lacking the gamma interferon (IFN-gamma) receptor with S. mansoni larvae and studied the development of hepatic granulomas in these mutant mice in comparison to that in control wild-type mice. In the absence of IFN-gamma activity, a dramatic reduction in the size and architecture of the granuloma was observed. Granulomas from mutant mice were smaller than those from the control group and showed a significant reduction in the number of infiltrating inflammatory cells. Moreover, they appear to prematurely progress to the chronic phase of the reaction at a time when the control group still has acute inflammation. Our data suggests a pivotal role for IFN-gamma in the early events of the granulomatous reaction in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.