ArticleInfection and immunity1997
Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Strain-specific immune response patterns toInfection and immunity · 2026Article
- Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission.Nature communications · 2025Article
- Immune Response toCurrent issues in molecular biology · 2021Article
- Innate immune responses in Lyme borreliosis: enhanced tumour necrosis factor-alpha and interleukin-12 in asymptomatic individuals in response to live spirochetes.Clinical and experimental immunology · 2005Article
- Beta2 integrins control the severity of murine Lyme carditis.Infection and immunity · 2005Article
- Dendritic cells transduced with an adenovirus vector encoding interleukin-12 are a potent vaccine for invasive pulmonary aspergillosis.Genes and immunity · 2005Article
- A live and inactivated Chlamydia trachomatis mouse pneumonitis strain induces the maturation of dendritic cells that are phenotypically and immunologically distinct.Infection and immunity · 2005Article
- Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection.Infection and immunity · 2004Article
- Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells.Infection and immunity · 2003Article
- Dendritic cells pulsed with intact Streptococcus pneumoniae elicit both protein- and polysaccharide-specific immunoglobulin isotype responses in vivo through distinct mechanisms.The Journal of experimental medicine · 2002Article
- Protection against pulmonary infection with Pseudomonas aeruginosa following immunization with P. aeruginosa-pulsed dendritic cells.Infection and immunity · 2001Article
- Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria.Infection and immunity · 2001Article
- Vaccination with Bordetella pertussis-pulsed autologous or heterologous dendritic cells induces a mucosal antibody response in vivo and protects against infection.Infection and immunity · 2001Article
- Immunohistochemical analysis of Lyme disease in the skin of naive and infection-immune rabbits following challenge.Infection and immunity · 2001Article
- Major histocompatibility complex class II-independent generation of neutralizing antibodies against T-cell-dependent Borrelia burgdorferi antigens presented by dendritic cells: regulation by NK and gammadelta T cells.Infection and immunity · 2001Article
- Fate of Mycobacterium tuberculosis within murine dendritic cells.Infection and immunity · 2001Article
- Molecular events of bacterial-induced maturation of dendritic cells.Journal of clinical immunology · 2000Review
- Analysis of mouse dendritic cell migration in vivo upon subcutaneous and intravenous injection.Immunology · 1999Article
- Mucosal immunity and tolerance: relevance to vaccine development.Immunological reviews · 1999Review
- Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo.Infection and immunity · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Borrelia burgdorferi-pulsed dendritic cells and epidermal cells were able to initiate the production of anti-outer surface protein A (OspA) antibody in vitro with normal T and B cells from either BALB/c or C3H/HeJ mice. Inhibition of anti-B. burgdorferi antibody production was observed after 3 days, but not after 2 days, of exposure of the antigen-presenting cells to tumor necrosis factor alpha +/- granulocyte-macrophage colony-stimulating factor. Furthermore, splenic dendritic cells pulsed in vitro with live B. burgdorferi spirochetes and then adoptively transferred into naive syngeneic mice mediated a protective immune response against tick-transmitted spirochetes. This protection appeared not to be due to killing of spirochetes in the feeding ticks, since ticks fed to repletion on B. burgdorferi-pulsed dendritic cell-sensitized mice still harbored live spirochetes. Western blot analysis of the sera collected from dendritic cell-sensitized mice demonstrated that the mice responded to a limited set of B. burgdorferi antigens, including OspA, -B, and -C compared to control groups that either had received unpulsed dendritic cells or were not treated. Finally, mice in the early stage of B. burgdorferi infection were able to develop anti-OspA antibody following injection with B. burgdorferi-pulsed dendritic cells. Our results demonstrate for the first time that adoptive transfer of B. burgdorferi-pulsed dendritic cells induces a protective immune response against tick-transmitted B. burgdorferi and stimulates the production of antibodies specific for a limited set of B. burgdorferi antigens in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.