ArticleInfection and immunity1997
Nonspecific immune responses and mechanisms of resistance to Eimeria papillata infections in mice.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 54 citations in OpenAlex.
- Impact of Temperature Variations on the Viability and Infectivity of Sporulated Eimeria papillata Oocysts in C57BL/6 Mice.Current microbiology · 2025Article
- Efficacy of myrrh extract against Eimeria labbeana-like experimental infection in Columba livia domestica: in vivo study.BMC veterinary research · 2024Article
- Toltrazuril and diclazuril: comparative evaluation of anti-coccidial drugs using a murine model.The Journal of veterinary medical science · 2022Article
- The Role of TLR2 and TLR4 in Recognition and Uptake of the Apicomplexan ParasitePathogens (Basel, Switzerland) · 2021Article
- Anthelmintic, anticoccidial and antioxidant activity ofSaudi journal of biological sciences · 2019Article
- The state of art of neutrophil extracellular traps in protozoan and helminthic infections.Bioscience reports · 2019Review
- Innate Lymphoid Cells in Protection, Pathology, and Adaptive Immunity During Apicomplexan Infection.Frontiers in immunology · 2019Review
- Nanoselenium prevents eimeriosis-induced inflammation and regulates mucin gene expression in mice jejunum.International journal of nanomedicine · 2018Article
- Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata.Parasitology research · 2015Article
- Dietary selenium affects intestinal development of Eimeria papillata in mice.Parasitology research · 2014Article
- Goblet cells and mucin related gene expression in mice infected with Eimeria papillata.TheScientificWorldJournal · 2013Article
- Differential miRNA expression in the mouse jejunum during garlic treatment of Eimeria papillata infections.Parasitology research · 2011Article
- Porcine coccidiosis--investigations on the cellular immune response against Isospora suis.Parasitology research · 2009Review
- Porcine isosporosis: infection dynamics, pathophysiology and immunology of experimental infections.Wiener klinische Wochenschrift · 2007Review
- Role of polymorphonuclear neutrophils in a murine model of Chlamydia psittaci-induced abortion.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe combined immunodeficient (SCID)-beige mice inoculated with the intracellular parasite Eimeria papillata produced significantly more oocysts during primary infections than inoculated immunodeficient SCID mice. Therefore, the addition of the beige mutation, which detrimentally affects neutrophil and natural killer (NK) cell functions, enhanced the parasites' ability to reproduce within the small intestine. To identify which of these two cell types is responsible for a protective immune response during primary infection, the following groups of mice were inoculated: (i) SCID mice depleted of neutrophils with antigranulocyte monoclonal antibody (RB6-8C5), (ii) C57BL/6 mice depleted of NK cells with the anti-NK-1.1 monoclonal antibody (PK136), and (iii) transgenic Tg epsilon26++ mice (T and NK cell deficient). To identify the mechanisms of immunity during primary and secondary infections, gamma interferon (IFN-gamma) knockout and perforin knockout mice were inoculated. Oocyst output was found to be significantly higher during primary infection for mice depleted of NK cells by administration of anti-NK-1.1 antibodies, for Tg epsilon26++ mice, and for IFN-gamma knockout mice. During secondary infections, only perforin knockout mice produced significantly more oocysts compared to control mice. Our observations suggest that NK cells inhibit E. papillata oocyst output during primary infection by the production of IFN-gamma and that this inhibition is independent of perforin. Immunity to reinfection does not require IFN-gamma but appears to be mediated, at least in part, by a perforin-dependent mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.