ArticleMolecular and cellular biology1997
Two evolutionarily conserved repression domains in the Drosophila Kruppel protein differ in activator specificity.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- From genes to patterns: a framework for modeling the emergence of embryonic development from transcriptional regulation.Frontiers in cell and developmental biology · 2025Article
- Molecular evolution and genetic diversity of defective chorion 1 in Anastrepha fraterculus and Anastrepha obliqua (Diptera, Tephritidae).Development genes and evolution · 2024Article
- Systematic identification and characterization of repressive domains in Drosophila transcription factors.The EMBO journal · 2023Article
- Tobacco transcription factors: novel insights into transcriptional regulation in the Solanaceae.Plant physiology · 2008Article
- EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters.Investigative ophthalmology & visual science · 2004Article
- Cell-type specificity of short-range transcriptional repressors.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein.Molecular and cellular biology · 2000Article
- Independent repressor domains in ZEB regulate muscle and T-cell differentiation.Molecular and cellular biology · 1999Article
- Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation.The EMBO journal · 1999Article
- dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo.The EMBO journal · 1998Article
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3 authors.
Funding
Abstract
To identify biologically functional regions in the product of the Drosophila melanogaster gene Kruppel, we cloned the Kruppel homolog from Drosophila virilis. Both the previously identified amino (N)-terminal repression region and the DNA-binding region of the D. virilis Kruppel protein are greater than 96% identical to those of the D. melanogaster Kruppel protein, demonstrating a selective pressure to maintain the integrity of each region during 60 million to 80 million years of evolution. An additional region in the carboxyl (C) terminus of Kruppel that was most highly conserved was examined further. A 42-amino-acid stretch within the conserved C-terminal region also encoded a transferable repression domain. The short, C-terminal repression region is a composite of three subregions of distinct amino acid composition, each containing a high proportion of either basic, proline, or acidic residues. Mutagenesis experiments demonstrated, unexpectedly, that the acidic residues contribute to repression function. Both the N-terminal and C-terminal repression regions were tested for the ability to affect transcription mediated by a variety of activator proteins. The N-terminal repression region was able to inhibit transcription in the presence of multiple activators. However, the C-terminal repression region inhibited transcription by only a subset of the activator proteins. The different activator specificities of the two regions suggest that they repress transcription by different mechanisms and may play distinct biological roles during Drosophila development.
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