ArticleMolecular and cellular biology1997
Nucleosomal structures of c-myc promoters with transcriptionally engaged RNA polymerase II.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II.Nucleic acids research · 2005Article
- Cdk7 is required for full activation of Drosophila heat shock genes and RNA polymerase II phosphorylation in vivo.Molecular and cellular biology · 2003Article
- Transcriptional consequences of topoisomerase inhibition.Molecular and cellular biology · 2001Article
- Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression.The EMBO journal · 2000Article
- The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes.Molecular and cellular biology · 1998Article
- Characterization of the TATA-less core promoter of the cell cycle-regulated cdc25C gene.Nucleic acids research · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organization of DNA into chromatin has been shown to contribute to a repressed state of gene transcription. Disruption of nucleosomal structure is observed in response to gene induction, suggesting a model in which RNA polymerase II (pol II) is recruited to the promoter upon reorganization of nucleosomes. Here we show that induction of c-myc transcription correlates with the disruption of two nucleosomes in the upstream promoter region. This nucleosomal disruption, however, is not necessary for the binding of pol II to the promoter. Transcriptionally engaged pol II complexes can be detected when the upstream chromatin is in a more closed configuration. Thus, upstream chromatin opening is suggested to affect activation of promoter-bound pol II rather than entry of polymerases into the promoter. Interestingly, pol II complexes are detectable in both sense and antisense transcriptional directions, but only complexes in the sense direction respond to activation signals resulting in processive transcription.
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Registered trials
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