ArticleMolecular and cellular biology1997
A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.Blood advances · 2019Article
- Genome-wide computational prediction and analysis of core promoter elements across plant monocots and dicots.PloS one · 2013Article
- Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression.Oncogene · 2007Article
- Regulation of the human LAT gene by the Elf-1 transcription factor.BMC molecular biology · 2006Article
- The T-cell receptor beta variable gene promoter is required for efficient V beta rearrangement but not allelic exclusion.Molecular and cellular biology · 2004Article
- A novel docking site on Mediator is critical for activation by VP16 in mammalian cells.The EMBO journal · 2003Article
- The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression.The Journal of experimental medicine · 2003Article
- Predicting transcription factor synergism.Nucleic acids research · 2002Article
- Use of chromatin immunoprecipitation to clone novel E2F target promoters.Molecular and cellular biology · 2001Article
- Novel critical role of a human Mediator complex for basal RNA polymerase II transcription.EMBO reports · 2001Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.The Journal of experimental medicine · 2000Article
- Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.Molecular and cellular biochemistry · 2000Review
- EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.Oncogene · 2000Article
- Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter.Oncogene · 1999Article
- TFII-I regulates Vbeta promoter activity through an initiator element.Molecular and cellular biology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T-cell receptor (TCR) beta-chain promoters have been characterized as nonstructured basal promoters that carry a single conserved ubiquitous cyclic AMP-responsive element. Our investigation of the human TCR beta gene uncovers a surprisingly complex and tissue-specific structure at the TCR Vbeta 8.1 promoter. The core of the promoter (positions -42 to +11) is recognized by the lymphoid cell-specific transcription factors Ets-1, LEF1, and AML1 as well as by CREB/ATF-1, as is demonstrated in gel shift and footprinting experiments. With the exception of LEF1, these factors activate transcription in T cells. Binding sites at the core region show little conservation with consensus sites. Nonetheless, CREB, Ets-1, and AML1 bind and activate cooperatively and very efficiently through the nonconsensus binding sites at the core promoter region. Moderate ubiquitous activation is further induced by CREB/ATF and Sp1 factors through proximal upstream elements. The tissue-specific core promoter structure is apparently conserved in other T-cell-specifically expressed genes such as the CD4 gene. Our observations suggest that both the enhancer and the promoter have a complex tissue-specific structure whose functional interplay potentiates T-cell-specific transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.