ArticleThe EMBO journal1997
Identification and characterization of a yeast homolog of U1 snRNP-specific protein C.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Domain Requirements and Genetic Interactions of the Mud1 Subunit of theG3 (Bethesda, Md.) · 2019Article
- CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.Nature communications · 2017Article
- Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1.RNA (New York, N.Y.) · 2015Article
- Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.Nucleic acids research · 2014Article
- Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors.Nucleic acids research · 2013Article
- Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome.PeerJ · 2013Article
- A novel intra-U1 snRNP cross-regulation mechanism: alternative splicing switch links U1C and U1-70K expression.PLoS genetics · 2013Article
- RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation.The EMBO journal · 2011Article
- Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases.Nucleic acids research · 2006Review
- Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.The EMBO journal · 2002Article
- Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles.RNA (New York, N.Y.) · 2001Article
- A new twist on RNA helicases: DExH/D box proteins as RNPases.Nature structural biology · 2001Review
- Yeast U1 snRNP-pre-mRNA complex formation without U1snRNA-pre-mRNA base pairing.RNA (New York, N.Y.) · 2001Article
- Multiple roles for the yeast SUB2/yUAP56 gene in splicing.Genes & development · 2001Article
- Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex.Genes & development · 1999Article
- Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection.Genes & development · 1999Article
- A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing.Molecular and cellular biology · 1999Article
- Elevated levels of a U4/U6.U5 snRNP-associated protein, Spp381p, rescue a mutant defective in spliceosome maturation.Molecular and cellular biology · 1999Article
- Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation.The EMBO journal · 1998Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
U1C is one of the three human U1 small nuclear ribonucleoprotein (snRNP)-specific proteins and is important for efficient complex formation between U1 snRNP and the pre-mRNA 5' splice site. We identified a hypothetical open reading frame in Saccharomyces cerevisiae as the yeast homolog of the human U1C protein. The gene is essential, and its product, YU1C, is associated with U1 snRNP. YU1C depletion gives rise to normal levels of U1 snRNP and does not have any detectable effect on U1 snRNP assembly. YU1C depletion and YU1C ts mutants affect pre-mRNA splicing in vivo, and extracts from these strains form low levels of commitment complexes and spliceosomes in vitro. These experiments indicate a role for YU1C in snRNP function. Structure probing with RNases shows that only the U1 snRNA 5' arm is hypersensitive to RNase I digestion when YU1C is depleted. Similar results were obtained with YU1C ts mutants, indicating that U1C contributes to a proper 5' arm structure prior to its base pairing interaction with the pre-mRNA 5' splice site.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.