ArticleThe EMBO journal1997
c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter.Molecular carcinogenesis · 2022Article
- Article
- Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3.Nucleic acids research · 2018Article
- ZEB Proteins in Leukemia: Friends, Foes, or Friendly Foes?HemaSphere · 2018Review
- Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles.The EMBO journal · 2017Article
- ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression.Oncogene · 2015Article
- Direct repression of MYB by ZEB1 suppresses proliferation and epithelial gene expression during epithelial-to-mesenchymal transition of breast cancer cells.Breast cancer research : BCR · 2013Article
- Pax7 is regulated by cMyb during early neural crest development through a novel enhancer.Development (Cambridge, England) · 2013Article
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.Cellular and molecular life sciences : CMLS · 2012Review
- Expanding roles of ZEB factors in tumorigenesis and tumor progression.American journal of cancer research · 2011Article
- A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment.Nucleic acids research · 2010Article
- ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1.Oncogene · 2010Article
- Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights.Molecular and cellular biochemistry · 2008Article
- Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal.Cell stem cell · 2008Article
- The biology of the Ets1 proto-oncogene.Molecular cancer · 2003Review
- Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.The EMBO journal · 2003Article
- Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.The EMBO journal · 2003Article
- Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.American journal of human genetics · 2003Article
- Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage.Molecular and cellular biology · 2001Article
- Ets target genes: past, present and future.Oncogene · 2000Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Zfh family of zinc finger/homeodomain proteins was first identified in Drosophila where it is required for differentiation of tissues such as the central nervous system and muscle. ZEB, a vertebrate homolog of Zfh-1, binds a subset of E boxes and blocks myogenesis through transcriptional repression of muscle genes. We present evidence here that ZEB also has an important role in controlling hematopoietic gene transcription. Two families of transcription factors that are required for normal hematopoiesis are c-Myb and Ets. These factors act synergistically to activate transcription, and this synergy is required for transcription of at least several important hematopoietic genes. ZEB blocks the activity of c-Myb and Ets individually, but together the factors synergize to resist this repression. Such repression imposes a requirement for both c-Myb and Ets for transcriptional activity, providing one explanation for why synergy between these factors is important. The balance between repression by ZEB and transcriptional activation by c-Myb/Ets provides a flexible regulatory mechanism for controlling gene expression in hematopoietic cells. We demonstrate that one target of this positive/negative regulation in vivo is the alpha4 integrin, which play a key role in normal hematopoiesis and function of mature leukocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.