ArticleMolecular pathology : MP1997
HHV8 and Kaposi's sarcoma: a time cohort study.
Article in Molecular pathology : MP, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed.
- The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency.Future microbiology · 2011Review
- Real-time Fluorescent PCR Techniques to Study Microbial-Host Interactions.Methods in microbiology · 2004Review
- Evaluation of susceptibility of human herpesvirus 8 to antiviral drugs by quantitative real-time PCR.Journal of clinical microbiology · 2003Article
- Calibrated real-time PCR assay for quantitation of human herpesvirus 8 DNA in biological fluids.Journal of clinical microbiology · 2002Article
- Real-time PCR in virology.Nucleic acids research · 2002Review
- Cyclin D1 expression and HHV8 in Kaposi sarcoma.Journal of clinical pathology · 1999Article
- CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.Molecular pathology : MP · 1999Article
- Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.Nature · 1998Article
- Human herpes virus 8 (HHV-8) in Kaposi's sarcoma: lack of association with Bcl-2 and p53 protein expression.Molecular pathology : MP · 1998Article
- In cell amplification.Molecular pathology : MP · 1998Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe recent finding that human herpes virus 8 (HHV8) is found in the majority of Kaposi's sarcoma (KS) cases supports the epidemiological observation that the tumour may be caused by an infectious agent. This study aimed to address when and how HHV8 evolved.
methodsA cohort of African endemic KS (49 samples from 45 patients) and European KS (18 samples from 13 patients), spanning 27 years, was assessed for the presence of HHV8 by both standard solution phase polymerase chain reaction (PCR) and the newly described technique of TaqMan PCR.
resultsHHV8 was present in approximately 49% (24 of 49 tissue samples) of the African cases and in more than 90% (16 of 18 tissue samples) of the European cohort, in keeping with recent seroepidemiological data.
conclusionsHHV8 is strongly linked to the development of KS; however, in some patients, other factors may operate. The utility and flexibility of TaqMan PCR in detecting low copy viral target in human tissues was demonstrated.
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