ArticleThe Journal of cell biology1997
Interactions between germ cells and extracellular matrix glycoproteins during migration and gonad assembly in the mouse embryo.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 124 citations in OpenAlex.
- Primordial germ cells experience increasing physical confinement and DNA damage during migration in the mouse embryo.Science advances · 2026Article
- Article
- The fantastic voyage: primordial germ cell migration through the developing mouse embryo.Biochemical Society transactions · 2025Article
- The matrisome landscape controlling in vivo germ cell fates.Nature communications · 2024Article
- The journey of a generation: advances and promises in the study of primordial germ cell migration.Development (Cambridge, England) · 2024Article
- Stay on the road: from germ cell specification to gonadal colonization in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Germline stem cells in human.Signal transduction and targeted therapy · 2022Review
- Presence of the matrix metalloproteinases during the migration of the primordial germ cells in zebrafish gonadal ridge.Cell and tissue research · 2021Article
- Human pluripotent stem cell-derived DDX4 and KRT-8 positive cells participate in ovarian follicle-like structure formation.iScience · 2021Article
- Mammalian germ cell migration during development, growth, and homeostasis.Reproductive medicine and biology · 2019Review
- Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse.Nature communications · 2019Article
- Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration.Frontiers in cell and developmental biology · 2019Article
- High salt-induced excess reactive oxygen species production resulted in heart tube malformation during gastrulation.Journal of cellular physiology · 2018Article
- Finding their way: themes in germ cell migration.Current opinion in cell biology · 2016Review
- Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse.Developmental biology · 2016Article
- Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate.Nature communications · 2015Article
- Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.Current topics in membranes · 2015Review
- On the fate of primordial germ cells injected into early mouse embryos.Developmental biology · 2014Article
- Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro.Biology open · 2013Article
- Defining the neighborhoods that escort the oocyte through its early life events and into a functional follicle.Molecular reproduction and development · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cells are known to bind to individual extracellular matrix glycoproteins in a complex and poorly understood way. Overall strength of adhesion is thought to be mediated by a combinatorial mechanism, involving adhesion of a cell to a variety of binding sites on the target glycoproteins. During migration in embryos, cells must alter their overall adhesiveness to the substrate to allow locomotion. The mechanism by which this is accomplished is not well understood. During early development, the cells destined to form the gametes, the primordial germ cells (PGCs), migrate from the developing hind gut to the site where the gonad will form. We have used whole-mount immunocytochemistry to study the changing distribution of three extracellular matrix glycoproteins, collagen IV, fibronectin, and laminin, during PGC migration and correlated this with quantitative assays of adhesiveness of PGCs to each of these. We show that PGCs change their strength of adhesion to each glycoprotein differentially during these stages. Furthermore, we show that PGCs interact with a discrete tract of laminin at the end of migration. Closer analysis of the adhesion of PGCs to laminin revealed that PGCs adhere particularly strongly to the E3 domain of laminin, and blocking experiments in vitro suggest that they adhere to this domain using a cell surface proteoglycan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.