ArticleThe Journal of cell biology1997
KLP38B: a mitotic kinesin-related protein that binds PP1.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genome-Wide Expression Profiling and Phenotypic Analysis of Downstream Targets Identify the Fox Transcription Factor Jumeau as a Master Regulator of Cardiac Progenitor Cell Division.International journal of molecular sciences · 2024Article
- Acentrosomal spindles assemble from branching microtubule nucleation near chromosomes in Xenopus laevis egg extract.Nature communications · 2023Article
- The Drosophila Forkhead/Fox transcription factor Jumeau mediates specific cardiac progenitor cell divisions by regulating expression of the kinesin Nebbish.Scientific reports · 2021Article
- Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.Human molecular genetics · 2019Article
- Citron kinase controls a molecular network required for midbody formation in cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion.Journal of neurochemistry · 2009Article
- Drosophila Uri, a PP1alpha binding protein, is essential for viability, maintenance of DNA integrity and normal transcriptional activity.BMC molecular biology · 2008Article
- KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers.Oncogene · 2005Article
- The roles of microtubule-based motor proteins in mitosis: comprehensive RNAi analysis in the Drosophila S2 cell line.The Journal of cell biology · 2003Article
- Ectopic expression of inhibitors of protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development.Genetics · 2003Article
- Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila.EMBO reports · 2003Article
- Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.The Biochemical journal · 2002Article
- Article
- Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye.Molecular and cellular biology · 2001Article
- Regulation of organelle movement in melanophores by protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2A (PP2A).The Journal of cell biology · 1998Article
- A chromatin-associated kinesin-related protein required for normal mitotic chromosome segregation in Drosophila.The Journal of cell biology · 1997Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified a new member of the kinesin superfamily in Drosophila, KLP38B (kinesin-like protein at 38B). KLP38B was isolated through its two-hybrid interaction with the catalytic subunit of type 1 serine/threonine phosphoprotein phosphatase (PP1). We demonstrate that recombinant KLP38B and PP1 associate in vitro. This is the first demonstration of direct binding of a kinesin-related protein to a regulatory enzyme. Though most closely related to the Unc-104 subfamily of kinesin-related proteins, KLP38B is expressed only in proliferating cells. KLP38B mutants show cell proliferation defects in many tissues. KLP38B is required for normal chromatin condensation as embryos from KLP38B mutant mothers have undercondensed chromatin at metaphase and anaphase. This is the first time that a kinesin-related protein has been shown to have such a role. Incomplete lethality of a strong KLP38B allele suggests partial redundancy with one or more additional kinesin-related proteins.
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