ArticleUrological research1997
Comparison of adrenoceptor subtype expression in porcine and human bladder and prostate.
Article in Urological research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 106 citations in OpenAlex.
- The Crosstalk between Nerves and Cancer-A Poorly Understood Phenomenon and New Possibilities.Cancers · 2024Review
- Adrenoceptors in the Lower Urinary Tract.Handbook of experimental pharmacology · 2024Review
- Sex and Gender Differences in the Pharmacology of the Overactive Urinary Bladder.Handbook of experimental pharmacology · 2023Review
- Inhibition of prejunctional parasympathetic pathways by βFrontiers in pharmacology · 2023Article
- β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1.Molecular cancer research : MCR · 2020Article
- Toll-like receptor 9 regulates metabolic profile and contributes to obesity-induced benign prostatic hyperplasia in mice.Pharmacological reports : PR · 2020Article
- Single-Cell Transcriptomic Map of the Human and Mouse Bladders.Journal of the American Society of Nephrology : JASN · 2019Article
- ADRB2-Targeting Therapies for Prostate Cancer.Cancers · 2019Review
- Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium.Naunyn-Schmiedeberg's archives of pharmacology · 2018Review
- Diabetes and beta-adrenergic blockage are risk factors for metastatic prostate cancer.World journal of surgical oncology · 2017Article
- β-Adrenergic Receptor Signaling in Prostate Cancer.Frontiers in oncology · 2014Review
- Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol-response curve in porcine detrusor muscle.Arab journal of urology · 2012Article
- Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH).British journal of pharmacology · 2011Review
- A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors.PloS one · 2010Article
- β-Adrenergic receptor subtype expression in myocyte and non-myocyte cells in human female bladder.Cell and tissue research · 2010Article
- Can [I]-Iodocyanopindolol Label β(3)-Adrenoceptors in Rat Urinary Bladder?Frontiers in pharmacology · 2010Article
- Inhibitory effects of various L-type and T-type calcium antagonists on electrically generated, potassium-induced and carbachol-induced contractions of porcine detrusor muscle.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2006Article
- Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate.British journal of pharmacology · 2006Review
- Medical therapy for benign prostatic hyperplasia: new terminology, new concepts, better choices.Reviews in urology · 2006Article
- The role of beta(3)-adrenoceptors in mediating relaxation of porcine detrusor muscle.British journal of pharmacology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have quantified and characterized alpha 1-, alpha 2- and beta-adrenoceptor subtypes in porcine bladder detrusor and bladder neck, human bladder detrusor, and porcine and human prostate. alpha 1-, alpha 2- and beta-adrenoceptor were identified in radioligand binding studies using [3H]prazosin, [3H]RX 821002 and [125I]iodocyanopindolol, respectively, as the radioligands. In porcine male and female detrusor and bladder neck and male prostate, adrenoceptors were detected in the order of abundance beta > alpha 2 >> alpha 1 (not detectable), with no major difference between the sexes or between detrusor and bladder neck. In human detrusor and prostate the order of abundance was beta > alpha 2 >> alpha 1 (not detectable) and beta >> alpha 1 > alpha 2, respectively. The alpha 2-adrenoceptors in all tissues were homogeneously of the alpha 2A-subtype as evidenced by competition binding studies with yohimbine, prazosin, ARC 239 and oxymetazoline. The beta-adrenoceptors represented a mixed population with a dominance of the beta 2-subtype in all tissues as demonstrated by competition binding with ICI 118,551 and CGP 20,712A. We conclude that pigs may be a suitable model for studies of detrusor function with respect to adrenoceptor expression. They may be less suitable for studies of bladder neck or prostate function.
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