ArticleThorax1997
Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients.
Article in Thorax, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 240 citations in OpenAlex.
- Trial
- MMP-9, TIMP-1 and inflammatory cells in sputum from COPD patients during exacerbation.Respiratory research · 2005Trial
- Interleukin-17A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust.Respiratory research · 2005Trial
- Extracellular iron and the lung microbiome in smoking and COPD.ERJ open research · 2025Article
- The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases.International journal of molecular sciences · 2022Review
- Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.BMC pulmonary medicine · 2020Observational
- Loki zupa alleviates inflammatory and fibrotic responses in cigarette smoke induced rat model of chronic obstructive pulmonary disease.Chinese medicine · 2020Article
- Neutrophil gelatinase-associated lipocalin as a complementary biomarker for the asthma-chronic obstructive pulmonary disease overlap.Journal of thoracic disease · 2018Article
- Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials.Journal of thoracic disease · 2018Review
- Matrix Metalloproteinases in Non-Neoplastic Disorders.International journal of molecular sciences · 2016Review
- Ascorbate attenuates pulmonary emphysema by inhibiting tobacco smoke and Rtp801-triggered lung protein modification and proteolysis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse?Mediators of inflammation · 2016Review
- Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.International journal of chronic obstructive pulmonary disease · 2016Article
- MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation.Molecular imaging and biology · 2015Article
- Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection.Respiratory research · 2015Observational
- Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse.Mediators of inflammation · 2015Article
- Budesonide ameliorates lung function of the cigarette smoke-exposed rats through reducing matrix metalloproteinase-1 content.International journal of clinical and experimental pathology · 2015Article
- Indacaterol inhibits tumor cell invasiveness and MMP-9 expression by suppressing IKK/NF-κB activation.Molecules and cells · 2014Article
- Antimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis.Antimicrobial agents and chemotherapy · 2014Article
- Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels.American journal of physiology. Lung cellular and molecular physiology · 2014Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMatrix degradation in emphysema has long been attributed to the action of neutrophil elastase (NE). More recently a role for other proteases, particularly the matrix metalloproteinases (MMPs), in the pathogenesis of this disease has been proposed. To date, however, the presence of MMPs in the lungs of patients with emphysema has not been demonstrated.
methodsSamples of bronchoalveolar lavage (BAL) fluid from 10 patients with emphysema and from control subjects matched for sex and current smoking status were assessed for collagenase, gelatinase, and NE activity. Pulmonary function tests and computed tomographic (CT) scans were carried out on all study subjects.
resultsCollagenase activity was detected in BAL fluid samples from all emphysematous patients but in only one smoking control (p < 0.001). Gelatinase B was present in six patients and in two smoking controls (p < 0.03). The concomitant presence of gelatinase B in complex with lipocalin (NGAL) in the gelatinase positive samples suggests that the neutrophil is a significant source of the gelatinase B observed. NE was detected in six of the 10 patients with emphysema and in two smoking controls (p < 0.01), indicating that collagenase was more useful in discriminating between disease and control groups than either NE or gelatinase B. No relationship was observed between any of the enzymes measured and pulmonary function or CT density score.
conclusionsThis study demonstrates, for the first time, the presence of increased levels of matrix metalloproteinases in the lungs of patients with emphysema and suggests that, in BAL fluid, collagenase activity may be a better indicator of the presence of emphysema than elastase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.